[Correlation of FGF2 and TGF-β1 with benign prostatic hyperplasia: Progress in research]

Benign prostatic hyperplasia (BPH) is a most common disorder in the elderly. The development and growth of the prostate are regulated by androgens and growth factors, and the latter are secreted by prostatic epithelial and mesenchymal cells and play a key role. As the family members of FGF and TGF-β, FGF2 and TGF-β1 are the most representative growth factors in the prostate, involved in the regulation of such biological processes as proliferation, apoptosis, migration and differentiation of prostate cells, which provides a theoretical basis for the clinical application of FGF- and TGF-β-targeted drugs in the treatment of BPH.