Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In Response.

Anesthesia and analgesia·2026
Same author

Atg23 interacts with both the N- and C-termini of Atg9 via a hydrophobic binding pocket.

The Journal of biological chemistry·2026
Same author

A GUV-based assay to reconstitute membrane tethering in vitro.

Molecular biology of the cell·2026
Same author

Membrane composition-dependent patterning of Rho and F-actin in an artificial cell cortex.

Molecular biology of the cell·2026
Same author

Thromboelastography to Support Clinical Decision Making in Patients with Peripheral Artery Disease.

Diagnostics (Basel, Switzerland)·2025
Same author

Atg23 Interacts With Both the N- and C-termini of Atg9 Via a Hydrophobic Binding Pocket.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Jul 13, 2025

Basic Research in Plasma Medicine - A Throughput Approach from Liquids to Cells
07:37

Basic Research in Plasma Medicine - A Throughput Approach from Liquids to Cells

Published on: November 17, 2017

12.9K

Large-scale real-world data analysis of source plasma collections using a novel technology-enabled nomogram.

Eva Hellman1, Zorayr Manukyan2, Karen Mkhitaryan2

  • 1Global Medical Office, Haemonetics Corporation, Boston, Massachusetts, USA.

Transfusion
|October 15, 2023
PubMed
Summary

A new personalized nomogram (PERS) for plasma collection is safe and effective, increasing plasma volume by 8.5% compared to the standard nomogram (STAN). Donor safety and return rates were maintained, helping meet the demand for plasma-derived therapies.

Keywords:
donor safetynomogramplasmaplasma donationplasma donorplasmapheresisrepeat donation

More Related Videos

Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins
10:05

Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins

Published on: August 7, 2014

13.9K
Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis
07:40

Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis

Published on: March 20, 2021

16.8K

Related Experiment Videos

Last Updated: Jul 13, 2025

Basic Research in Plasma Medicine - A Throughput Approach from Liquids to Cells
07:37

Basic Research in Plasma Medicine - A Throughput Approach from Liquids to Cells

Published on: November 17, 2017

12.9K
Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins
10:05

Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins

Published on: August 7, 2014

13.9K
Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis
07:40

Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis

Published on: March 20, 2021

16.8K

Area of Science:

  • Biomedical Sciences
  • Pharmacology
  • Public Health

Background:

  • Growing demand for plasma-derived medicinal products necessitates efficient and safe plasma collection methods.
  • The standard FDA-issued nomogram (STAN) has guided US plasma collection targets since 1992.
  • A novel personalized nomogram (PERS) was developed to potentially improve collection volumes and safety.

Purpose of the Study:

  • To evaluate the safety and efficacy of the personalized nomogram (PERS) using real-world data (RWD).
  • To compare the incidence of significant hypotensive adverse events (AEs) between PERS and STAN.
  • To assess the impact of PERS on average plasma collection target volumes and donor return rates.

Main Methods:

  • A non-inferiority (NI) analysis compared PERS's hypotensive AE rate against historical STAN data.
  • Real-world data from 4,816,784 donations by 414,957 donors were analyzed.
  • Average target volumes and weekly donor return rates were compared between PERS and STAN.

Main Results:

  • PERS demonstrated a low rate of significant hypotensive AEs (0.0998%), showing strong non-inferiority to STAN.
  • Average plasma collection target volumes increased by 66.39 mL (8.49%) with PERS (p < .0001).
  • Consecutive weekly donor return rates were consistent between PERS (73.6%) and STAN (74.1%).

Conclusions:

  • The personalized nomogram (PERS) is confirmed as safe and effective in a large-scale real-world dataset.
  • PERS can help meet the increasing demand for plasma-derived therapies by increasing collection volume by approximately 8.5%.
  • The novel nomogram maintains donor safety and return rates, offering a viable alternative to the standard approach.