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Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease
Published on: June 23, 2023
The interaction between alpha-synuclein and mitochondrial dysfunction in Parkinson's disease
Hong-Yan Li1, De-Shui Liu2, Ying-Bo Zhang2
1Department of Basic Medical College, Heilongjiang University of Chinese Medicine, Haerbin 150000, PR China.
Abstract:
Parkinson's disease (PD) is an aging-associated neurodegenerative disorder with the hallmark of abnormal aggregates of alpha-synuclein (α-syn) in Lewy bodies (LBs) and Lewy neurites (LNs). Currently, pathogenic α-syn and mitochondrial dysfunction have been considered as prominent roles that give impetus to the PD onset. This review describes the α-syn pathology and mitochondrial alterations in PD, and focuses on how α-syn interacts with multiple aspects of mitochondrial homeostasis in the pathogenesis of PD.
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