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Updated: Jul 13, 2025
Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer
Published on: August 2, 2024
Roles of TRPM7 in ovarian cancer
Zhi-Bin Wang1, Xiu Zhang1, Fen Xiao1
1Hunan Gynecological Tumor Clinical Research Center; Hunan Key Laboratory of Cancer Metabolism; Hunan Cancer Hospital, and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410008, PR China.
Abstract:
Ovarian cancer stands as the prevailing gynecologic malignancy, afflicting over 313,959 individuals annually worldwide, accompanied by more than 207,252 fatalities. Perturbations in calcium signaling contribute significantly to the pathogenesis of numerous cancers, including ovarian cancer, wherein alterations in calcium transporter expression have been reported. Overexpression of TRPM7, a prominent calcium transporter, has been linked to adverse prognostic outcomes in various cancer types. The focus of this comprehensive review centers around delineating the oncogenic role of TRPM7 in cancer development and exploring its therapeutic potential as a target in combating this disease. Notably, TRPM7 fosters cancer invasion, metastasis, and uncontrolled cell proliferation, thereby perpetuating the expansion and reinforcement of these malignant entities. Furthermore, this review takes ovarian cancer as an example and summarizes the "dual-mode" regulatory role of TRPM7 in cancer. Within the domain of ovarian cancer, TRPM7 assumes the role of a harsh tyrant, firmly controlling the calcium ion signaling pathway and metabolic reprogramming pathways.
Insights
Transient Receptor Potential Melastatin 7 (TRPM7) is overexpressed in ovarian cancer, driving invasion, metastasis, and proliferation. Targeting TRPM7 offers therapeutic potential against this gynecologic malignancy.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Ovarian cancer is a leading cause of cancer-related death globally.
- Calcium signaling dysregulation is implicated in cancer pathogenesis.
- TRPM7, a calcium transporter, is overexpressed in various cancers, correlating with poor prognosis.
Purpose of the Study:
- To review the oncogenic role of TRPM7 in cancer development.
- To explore TRPM7 as a therapeutic target for cancer treatment.
- To elucidate the dual-mode regulatory function of TRPM7 in ovarian cancer.
Main Methods:
- Literature review focusing on TRPM7's role in cancer.
- Analysis of studies investigating TRPM7 expression and function.
- Examination of TRPM7's impact on cellular processes like invasion, metastasis, and proliferation.
Main Results:
- TRPM7 overexpression promotes cancer cell invasion, metastasis, and proliferation.
- TRPM7 acts as a critical regulator in ovarian cancer, controlling calcium signaling and metabolic reprogramming.
- TRPM7 exhibits a dual-mode regulatory role in cancer progression.
Conclusions:
- TRPM7 plays a significant oncogenic role in ovarian cancer.
- TRPM7 represents a promising therapeutic target for ovarian cancer.
- Understanding TRPM7's regulatory mechanisms is crucial for developing novel cancer therapies.
