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Updated: Jun 25, 2026
11:17
A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
Published on: August 11, 2018
Drs. Konsta and van der Horst-Bruinsma reply
Maria Konsta1, Irene E van der Horst-Bruinsma2
1Maria Konsta, MD, PhD, Department of Rheumatology Sismanoglion Hospital, Athens, Greece.
The Journal of Rheumatology
|October 15, 2023
Summary
This study investigated hip involvement in ankylosing spondylitis (AS) patients receiving tumor necrosis factor inhibitors (TNFi). We analyzed the prevalence and radiographic progression of hip disease in this patient group.
Area of Science:
- Rheumatology
- Immunology
- Radiology
Background:
- Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the axial skeleton.
- Tumor necrosis factor inhibitors (TNFi) are a key treatment for AS, but their effect on hip involvement requires further study.
- Hip involvement in AS can significantly impact patient mobility and quality of life.
Discussion:
- The prevalence and radiographic progression of hip disease in AS patients treated with TNFi were examined.
- This analysis provides insights into the long-term outcomes of TNFi therapy concerning hip joint health.
- Understanding these patterns is crucial for optimizing AS management.
Key Insights:
- The study quantifies the occurrence of hip involvement in AS patients undergoing TNFi treatment.
- Radiographic evidence of disease progression in the hip joint was assessed.
- Findings contribute to the evidence base for TNFi efficacy and safety in AS management.
Outlook:
- Further research should explore specific TNFi agents and their differential effects on hip involvement.
- Longitudinal studies are needed to fully elucidate the long-term impact of TNFi on hip structure in AS.
- This work may inform clinical guidelines for monitoring and managing hip disease in AS patients treated with biologics.
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