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Updated: Jul 13, 2025

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Lifestyle in bipolar disorder: A cross-sectional study
Mario Simjanoski1, Taiane de Azevedo Cardoso2, Benicio N Frey3
1Neuroscience Graduate Program, McMaster University, 1280 Main St. West, Hamilton, ON, Canada; Department of Psychiatry and Behavioural Neurosciences, McMaster University, 1280 Main St. West, Hamilton, ON, Canada.
Individuals with bipolar disorder (BD) exhibit poorer lifestyle patterns across all assessed domains compared to healthy controls. These unhealthy lifestyle habits persist regardless of mood episode polarity in bipolar disorder.
Area of Science:
- Psychiatry
- Mental Health Research
- Lifestyle Medicine
Background:
- Lifestyle behaviors significantly impact mental health.
- Limited research has explored lifestyle as a multidimensional construct in bipolar disorder (BD).
- Understanding lifestyle patterns in BD is crucial for targeted interventions.
Purpose of the Study:
- To compare lifestyle patterns between individuals with BD and healthy controls (HCs).
- To investigate lifestyle domains using the Short Multidimensional Inventory Lifestyle Evaluation (SMILE) scale.
- To identify potential differences in lifestyle based on mood episode polarity in BD.
Main Methods:
- Cross-sectional study design.
- Inclusion of 46 individuals with BD and 50 HCs.
- Assessment using MINI, MADRS, YMRS, and the SMILE scale across seven lifestyle domains.
Main Results:
- Significant differences in total SMILE scores and all individual domains between BD and HC groups (p<0.05).
- Individuals with BD reported worse lifestyle patterns across all domains, irrespective of mood episode (depressive, manic, or mixed).
- No significant lifestyle differences were found between different mood episodes within the BD group.
Conclusions:
- Unhealthy lifestyle patterns are prevalent in individuals with BD, independent of mood episode polarity.
- Multidimensional lifestyle assessment is essential for identifying and addressing lifestyle clusters in BD.
- Findings underscore the need for integrated lifestyle interventions in BD management.
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