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Chemical Triphosphorylation of Oligonucleotides
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Prodrug-Type Phosphotriester Oligonucleotides with Linear Disulfide Promoieties Responsive to Reducing Environment

Norihito Sugimoto1, Junsuke Hayashi1, Ryohei Funaki1

  • 1Department of Bioorganic Chemistry, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, 4-20-1 Nasahara, Takatsuki, Osaka, 569-1094, Japan.

Chembiochem : a European Journal of Chemical Biology
|October 15, 2023
PubMed

Keywords:
antisense oligonucleotideslinear disulfide promoietiesphosphotriester modificationprodrugreductive activation

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