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Pharmacogenomics and adverse effects of anti-infective drugs in children

Xin Huang1, Biwen Hu1, Ling Ye1

  • 1Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, China.

Clinical and Experimental Pharmacology & Physiology
|October 15, 2023
PubMed

Insights

Genetic factors influence adverse drug reactions in children, especially with anti-infective drugs. This review examines pharmacogenomics of these drugs to guide safer, individualized pediatric medication use.

Area of Science:

  • Pharmacogenomics and Pharmacology
  • Pediatric Drug Safety

Background:

  • Adverse drug reactions (ADRs) are a significant concern in pediatric medication use, with genetic factors contributing to their occurrence.
  • Anti-infective drugs are frequently prescribed to children and are a common source of ADRs.
  • Existing pharmacogenomic guidelines for anti-infective drugs often lack specific data from pediatric populations.

Approach:

  • This review systematically examines the pharmacogenomics of anti-infective drugs.
  • It focuses on drugs recommended for gene-guided use in Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines.
  • The study explores the correlation between pharmacogenetic frequencies and ADR incidence in children.

Key Points:

  • Pharmacogenomic data in pediatric populations are limited, hindering personalized anti-infective therapy.
  • Understanding genetic variations is crucial for predicting and preventing ADRs in children.
  • Gene-guided anti-infective drug selection holds promise for improving pediatric drug safety.

Conclusions:

  • This systematic review synthesizes current knowledge on the pharmacogenomics of anti-infective drugs relevant to pediatric use.
  • It highlights the need for more pediatric-specific pharmacogenomic research to inform individualized treatment strategies.
  • The findings aim to guide future studies and clinical practice towards safer medication management in children.

Keywords:
adverse drug reactionsanti-infective drugschildrengene frequenciespharmacogenomics

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