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Regulatory T cells and cardiovascular diseases
Wangling Hu1,2,3, Jingyong Li1,2,3, Xiang Cheng1,2,3
1Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.
Chinese Medical Journal
|October 16, 2023
Summary
Regulatory T cells (Tregs) are crucial for cardiovascular health, offering both anti-inflammatory effects and promoting tissue repair in various heart diseases. Understanding their complex roles is key to developing new therapies for cardiovascular diseases (CVDs).
Area of Science:
- Immunology
- Cardiology
- Regenerative Medicine
Background:
- Inflammation is a key driver of cardiovascular diseases (CVDs).
- Regulatory T cells (Tregs) possess immunosuppressive and tissue repair functions.
- Tregs exhibit heterogeneity and unique phenotypes in the cardiovascular system, especially during CVDs.
Approach:
- This review summarizes Treg functional principles and their synergistic effects with other immune cells in CVDs.
- It examines the roles and therapeutic potential of Tregs across various cardiovascular conditions.
- The review synthesizes findings from clinical and basic studies on Treg mechanisms in CVDs.
Key Points:
- Tregs are vital for maintaining cardiovascular tissue homeostasis and repair.
- They exert anti-inflammatory effects and actively promote myocardial regeneration and vascular repair.
- Tregs contribute to the stability of the cardiovascular microenvironment.
Conclusions:
- Tregs play a multifaceted role in cardiovascular diseases, extending beyond immunosuppression.
- Their therapeutic potential in CVDs is significant, targeting inflammation and promoting regeneration.
- Further research into Treg mechanisms is essential for advancing cardiovascular medicine.
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