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Understanding the development of sarcopenic obesity
Danae C Gross1, C Ray Cheever1, John A Batsis1,2
1Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Expert Review of Endocrinology & Metabolism
|October 16, 2023
Summary
Sarcopenic obesity (SarcO), characterized by low muscle mass and excess fat, increases health risks. Further research is crucial for understanding and treating this complex condition.
Area of Science:
- Gerontology
- Metabolic Disorders
- Body Composition
Background:
- Sarcopenic obesity (SarcO) combines reduced muscle mass/function with excess body fat.
- This condition poses greater health risks than sarcopenia or obesity alone.
- Recognition of SarcO as a distinct clinical entity is growing.
Purpose of the Study:
- To review the current understanding of SarcO.
- To discuss challenges in defining and diagnosing SarcO.
- To summarize recent scientific advancements and future research directions.
Main Methods:
- Literature review of recent studies on SarcO.
- Synthesis of data on epidemiology and adverse events.
- Discussion of proposed pathophysiological mechanisms.
Main Results:
- SarcO presents diagnostic challenges.
- Epidemiological data on SarcO has emerged in the last decade.
- Potential mechanisms include aging, hormonal changes, inflammation, and genetics.
Conclusions:
- SarcO is a significant health concern requiring further investigation.
- Understanding its etiology is key to developing interventions.
- Future research should focus on clinical infrastructure, lifecourse, and treatments.
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