Granger Causality: A Review and Recent Advances
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Updated: Jul 13, 2025

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
Published on: August 7, 2017
1Department of Biostatistics, University of Washington, Seattle, Washington 98195-4322, USA.
Abstract:
Introduced more than a half-century ago, Granger causality has become a popular tool for analyzing time series data in many application domains, from economics and finance to genomics and neuroscience. Despite this popularity, the validity of this framework for inferring causal relationships among time series has remained the topic of continuous debate. Moreover, while the original definition was general, limitations in computational tools have constrained the applications of Granger causality to primarily simple bivariate vector autoregressive processes. Starting with a review of early developments and debates, this article discusses recent advances that address various shortcomings of the earlier approaches, from models for high-dimensional time series to more recent developments that account for nonlinear and non-Gaussian observations and allow for subsampled and mixed-frequency time series.
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