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Related Concept Videos

Criteria for Causality: Bradford Hill Criteria - II01:28

Criteria for Causality: Bradford Hill Criteria - II

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The Bradford Hill criteria serve as guidelines for establishing causative links in epidemiological research. Beyond Strength, Consistency, Specificity, and Temporality, key criteria also include Biological Gradient, Plausibility, Coherence, Experiment, and Analogy. These principles assist scientists in assessing the likelihood of causation in complex biological contexts. Below is a summary of these concepts:
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Causality in Epidemiology01:21

Causality in Epidemiology

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Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...
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Criteria for Causality: Bradford Hill Criteria - I01:30

Criteria for Causality: Bradford Hill Criteria - I

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The Bradford Hill criteria are a group of principles that provide a framework to determine a causal relationship between a specific factor and a disease. There are nine criteria that are pivotal in assessing causality in epidemiological studies. Here's a closer look at Strength, Consistency, Specificity, and Temporality criteria with definitions and examples:
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Correlation and Causation01:27

Correlation and Causation

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Statistical tests can calculate whether there is a relationship, or correlation, between independent and dependent variables. An indirect relationship of the variables signifies a correlation, while a direct relationship shows causation. If it is determined that no connection exists between the variables, then the correlation is a coincidence.
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
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Cause and Effect01:53

Cause and Effect

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While variables are sometimes correlated because one does cause the other, it could also be that some other factor, a confounding variable, is actually causing the systematic movement in our variables of interest. For instance, as sales in ice cream increase, so does the overall rate of crime. Is it possible that indulging in your favorite flavor of ice cream could send you on a crime spree? Or, after committing crime do you think you might decide to treat yourself to a cone?
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Inductive Effects on Chemical Shift: Overview01:27

Inductive Effects on Chemical Shift: Overview

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The protons in unsubstituted alkanes are strongly shielded with chemical shifts below 1.8 ppm. Methine, methylene, and methyl protons appear at approximately 1.7, 1.2 and 0.7 ppm, while the proton signal from methane appears at 0.23 ppm. An electronegative substituent, such as chlorine, withdraws the electron density from the protons, increasing their chemical shift. Progressive substitution of the hydrogens in methane by chlorine shifts the proton signals increasingly downfield, to 3.05 ppm in...
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Updated: Jul 13, 2025

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
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Granger Causality: A Review and Recent Advances.

Ali Shojaie1, Emily B Fox2

  • 1Department of Biostatistics, University of Washington, Seattle, Washington 98195-4322, USA.

Annual Review of Statistics and Its Application
|October 16, 2023
PubMed
Summary

Granger causality, a time series analysis tool, is debated for causal inference validity. Recent advances expand its application beyond simple models to complex, high-dimensional, and nonlinear data.

Keywords:
deep neural networksgraphical modelsmixed-frequency time seriesmultivariate time seriespenalized estimationvector autoregressive model

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Area of Science:

  • Time Series Analysis
  • Econometrics
  • Neuroscience
  • Genomics

Background:

  • Granger causality, introduced over 50 years ago, is widely used for time series analysis.
  • Its validity for inferring causal relationships remains a subject of ongoing debate.
  • Computational limitations historically restricted Granger causality to bivariate vector autoregressive processes.

Purpose of the Study:

  • To review early developments and debates surrounding Granger causality.
  • To discuss recent advancements addressing the limitations of traditional Granger causality methods.
  • To highlight new models applicable to complex and diverse time series data.

Main Methods:

  • Review of historical Granger causality frameworks and their limitations.
  • Exploration of recent methodological advancements for time series analysis.
  • Discussion of models accommodating high-dimensional, nonlinear, and non-Gaussian data.

Main Results:

  • Recent advances have overcome limitations of early Granger causality models.
  • New methods enable analysis of high-dimensional, nonlinear, and non-Gaussian time series.
  • The framework now supports subsampled and mixed-frequency time series analysis.

Conclusions:

  • Granger causality has evolved significantly beyond its original bivariate application.
  • Modern approaches enhance the robustness and applicability of Granger causality for causal inference.
  • The reviewed advancements broaden the utility of Granger causality across various scientific domains.