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Searching for Strep A in the clinical environment during a human challenge trial: a sub-study protocol
Stephanie L Enkel1,2, Thel K Hla1,2,3, Bernadette Wong1
1Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Nedlands, WA, Australia.
Access Microbiology
|October 16, 2023
Summary
This study investigates how Streptococcus pyogenes (Strep A) spreads in clinical settings. Researchers used agar plates, droplet spread measurements, and environmental swabs to assess transmission routes for better control strategies.
Area of Science:
- Infectious Diseases
- Microbiology
- Public Health
Background:
- Streptococcus pyogenes (Strep A) causes significant global health issues.
- Current understanding of Strep A transmission is limited, especially regarding environmental and aerosol routes.
- Effective control strategies require detailed knowledge of all transmission pathways.
Purpose of the Study:
- To develop and detail an experimental methodology for assessing Strep A transmission potential in a clinical environment.
- To investigate potential transmission sources including airborne, droplet, and surface contamination.
- To inform interventions for controlling Strep A spread, particularly in endemic regions.
Main Methods:
- Utilizing selective agar settle plates to detect airborne and droplet Strep A.
- Measuring the distance of Strep A droplet spread during conversational speech.
- Conducting environmental swabbing of high-touch surfaces (personal and common) to detect Strep A presence.
Main Results:
- The methodology allows for assessing transmission potential from symptomatic, asymptomatic, and non-cases.
- Data on airborne, droplet, and surface contamination will be collected.
- This research will quantify transmission risks in a controlled clinical setting.
Conclusions:
- The developed methodology provides a comprehensive approach to understanding Strep A transmission dynamics.
- Findings will enhance knowledge of Strep A transmission opportunities, aiding in rheumatic fever prevention.
- Results will be disseminated through scientific publications and conferences.
