Related Experiment Video
Updated: Jul 13, 2025

Author Spotlight: Advancements in Intracardiac Echocardiography for Atrial Anatomy Assessment
Published on: June 30, 2023
A highly-detailed anatomical study of left atrial auricle as revealed by in-vivo computed tomography
Cesare Mantini1, Francesco Corradi2, Fabrizio Ricci1,3
1Department of Neuroscience, Imaging and Clinical Sciences, "G. D'Annunzio" University, Chieti, Italy.
Insights
The left atrial appendage (LAA) frequently forms blood clots, increasing stroke risk. Its variable shape is key to understanding clot formation and atrial fibrillation origins.
Area of Science:
- Cardiology
- Radiology
- Cardiac Surgery
Background:
- The left atrial appendage (LAA) is a primary source of intracardiac thrombi, significantly contributing to stroke incidence.
- The LAA is also a major origin site for atrial fibrillation in patients undergoing ablation.
- LAA morphology exhibits high variability, with shape and structure influencing thrombus formation.
Purpose of the Study:
- To review the normal anatomy of the LAA using various imaging techniques.
- To emphasize the relationship between LAA morphology and thrombus formation.
- To provide insights into LAA embryology.
Main Methods:
- Review of imaging techniques including computed tomography (CT), magnetic resonance imaging (MRI), and echocardiography.
- Analysis of LAA morphological characteristics.
- Discussion of LAA embryological development.
Main Results:
- Detailed description of normal LAA anatomy across different imaging modalities.
- Correlation established between specific LAA morphological features and the propensity for thrombus development.
- Embryological insights into LAA development.
Conclusions:
- Understanding LAA anatomy and its morphological variations is critical for clinicians.
- LAA morphology is a significant factor in thrombus formation and atrial fibrillation.
- Advanced imaging techniques are essential for LAA assessment.
Abstract:
The left atrial auricle (LAA) is the main source of intracardiac thrombi, which contribute significantly to the total number of stroke cases. It is also considered a major site of origin for atrial fibrillation in patients undergoing ablation procedures. The LAA is known to have a high degree of morphological variability, with shape and structure identified as important contributors to thrombus formation. A detailed understanding of LAA form, dimension, and function is crucial for radiologists, cardiologists, and cardiac surgeons. This review describes the normal anatomy of the LAA as visualized through multiple imaging techniques such as computed tomography (CT), magnetic resonance imaging (MRI), and echocardiography. Special emphasis is devoted to a discussion on how the morphological characteristics of the LAA are closely related to the likelihood of developing LAA thrombi, including insights into LAA embryology.
Related Concept Videos
Cardiac Catheterization III: Left Heart Catheterization
Anatomy of the Heart
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Mitral Stenosis II: Clinical features and Diagnostic Tests

