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Updated: Jul 13, 2025

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

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Metabolomics: A useful tool for ischemic stroke research.

Wentao Li1, Chongyu Shao2, Chang Li2

  • 1School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China.

Journal of Pharmaceutical Analysis
|October 16, 2023
PubMed
Summary

Metabolomics offers new ways to understand ischemic stroke (IS) by identifying biomarkers and mechanisms. This approach aids in precision medicine and the development of targeted treatments for IS.

Keywords:
BiomarkerIschemic strokeMetabolomicsPrecision medicineSingle cell metabolomics

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Area of Science:

  • Systems Biology
  • Metabolomics
  • Precision Medicine

Background:

  • Ischemic stroke (IS) is a complex disease with limited effective clinical strategies.
  • Metabolomics is emerging as a powerful tool in systems biology for disease research.
  • Current research lacks comprehensive understanding of IS pathogenesis and treatment.

Purpose of the Study:

  • To review recent advances in metabolomics for ischemic stroke (IS) research.
  • To explore the potential of metabolomics in identifying novel IS biomarkers and elucidating disease mechanisms.
  • To summarize the application of metabolomics in studying Chinese herbal formulations for IS and in single-cell analysis.

Main Methods:

  • Review of current literature on metabolomics applications in IS.
  • Analysis of metabolomic approaches for biomarker discovery and mechanism elucidation in IS.
  • Summary of studies utilizing metabolomics for Chinese herbal medicine and single-cell analysis.

Main Results:

  • Metabolomics shows promise for diagnosing IS, discovering drug targets, and monitoring treatment outcomes.
  • The review highlights the utility of metabolomics in understanding the molecular basis of IS.
  • Single-cell metabolomics is emerging as a key technology for detailed IS pathogenesis research.

Conclusions:

  • Metabolomics provides valuable insights into the multifactorial nature of ischemic stroke.
  • This approach has the potential to significantly advance IS diagnosis, treatment, and precision medicine.
  • Further development in metabolomics, especially single-cell metabolomics, will be crucial for future IS research.