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The Functions and Mechanisms of Long Non-coding RNA SNHGs in Gastric Cancer

Songhua Liu1, Yao Rong1, Mingzheng Tang1

  • 1The First Clinical Medical College of Gansu University of Chinese Medicine (Gansu Provincial Hospital), Lanzhou 730000, China.

Combinatorial Chemistry & High Throughput Screening
|October 16, 2023
PubMed

Insights

Small nucleolar host genes (SNHGs) are long non-coding RNAs (lncRNAs) involved in gastric cancer progression, affecting cell behavior and treatment resistance. Understanding SNHG functions offers potential for new diagnostic and therapeutic strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Gastric cancer (GC) remains a leading cause of cancer mortality worldwide.
  • Current treatments offer limited improvement in patient prognosis.
  • Long non-coding RNAs (lncRNAs) play crucial roles in tumor development.

Purpose of the Study:

  • To comprehensively review the biological functions of small nucleolar host genes (SNHGs) in gastric cancer.
  • To elucidate the molecular mechanisms underlying SNHG involvement in GC.
  • To discuss the clinical significance and therapeutic potential of SNHGs in gastric cancer.

Main Methods:

  • Literature review of studies on SNHGs in gastric cancer.
  • Analysis of SNHG roles in cancer cell proliferation, invasion, migration, EMT, apoptosis, chemotherapy resistance, and stemness.
  • Synthesis of information on molecular mechanisms and clinical relevance.

Main Results:

  • SNHGs are implicated in various malignant behaviors of gastric cancer cells.
  • These lncRNAs influence key processes including proliferation, invasion, migration, EMT, and apoptosis.
  • SNHGs are also linked to chemotherapy resistance and tumor stemness in GC.

Conclusions:

  • SNHGs are critical regulators in gastric cancer progression and treatment response.
  • Further research into SNHGs may reveal novel biomarkers for early detection.
  • Targeting SNHGs presents a promising avenue for developing innovative gastric cancer therapies.
Keywords:
Gastric cancerbiological functionhost genelong non-coding RNAmolecular mechanisms.small nucleolar RNA

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