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BioKA: a curated and integrated biomarker knowledgebase for animals
Yibo Wang1,2, Yihao Lin1,2, Sicheng Wu1,2
1National Genomics Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
Nucleic Acids Research
|October 16, 2023
Summary
BioKA is a new knowledgebase for animal biomarkers, addressing gaps in non-human disease research and breeding. It integrates diverse data, offering tools for exploring animal health and genetic resources.
Area of Science:
- Biomedical Informatics
- Animal Genomics
- Comparative Biology
Background:
- Biomarkers are crucial for personalized medicine, drug development, and breeding.
- Current animal biomarker resources are limited, primarily focusing on human diseases.
- A comprehensive resource for non-human animal biomarkers is needed for disease research and breeding.
Purpose of the Study:
- To develop BioKA, a curated and integrated knowledgebase for animal biomarkers.
- To consolidate information on animal species, diseases, traits, and associated biomarkers.
- To facilitate data exploration and understanding of animal health and genetics.
Main Methods:
- Curated and integrated data from 4747 references.
- Included 16,296 biomarkers across 31 species, covering gene/protein, miRNA, mutation, metabolic, circRNA, and lncRNA types.
- Integrated functional annotations (GOs, pathways) and constructed interactive networks (e.g., circRNA-miRNA-mRNA).
Main Results:
- BioKA contains 16,296 biomarkers for 951 diseases/traits in 31 species.
- Integrated diverse annotations and built interactive knowledge networks for efficient exploration.
- Provided breed/strain information for 13 species and homologous annotations for 8784 biomarkers across 16 species.
Conclusions:
- BioKA serves as a valuable resource for advancing animal disease research and understanding.
- The knowledgebase supports livestock breeding by providing genetic and biomarker information.
- BioKA enhances exploration of animal health through integrated data and interactive tools.
