Related Experiment Video
Updated: Jul 13, 2025
Author Spotlight: A Focus on Standardized Salivary Gland Ultrasound Protocol in Connective Tissue Disease Research
Published on: October 13, 2023
Evaluation of systemic immune and inflammatory biomarkers in hidradenitis suppurativa
1Department of Dermatology and Venereology, Health Sciences University Erzurum Regional Training and Research Hospital, Erzurum, Turkey. dr.zeynep.utlu@gmail.com.
Insights
New inflammatory markers, systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI), show promise for monitoring hidradenitis suppurativa (HS). These indicators are more reliable than other inflammation markers for HS patients.
Area of Science:
- Dermatology
- Immunology
- Clinical Pathology
Background:
- Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition.
- Understanding inflammatory markers in HS is crucial for effective management.
Purpose of the Study:
- To investigate the relationship between HS and complete blood count (CBC) parameters.
- To evaluate new inflammatory indices, systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI), in HS patients.
Main Methods:
- Retrospective review of 102 HS patients and 99 healthy controls.
- Comparison of CBC parameters, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), SII, and SIRI between groups.
Main Results:
- HS patients showed significant differences in CRP, neutrophil, lymphocyte, monocyte, and platelet counts, and PLR compared to controls.
- SII and SIRI were significantly elevated in HS patients.
- SIRI demonstrated a moderate correlation with CRP, while SII showed a low correlation. A high correlation was observed between SII and SIRI.
Conclusions:
- SII and SIRI are more reliable inflammatory biomarkers in HS patients than other tested parameters.
- SII and SIRI can serve as novel indicators for evaluating treatment response and monitoring HS progression.
Objective:
We aimed to investigate the interrelation of HS with CBC parameters and new inflammatory indicator parameters, systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI).
Patients And Methods:
102 patients diagnosed with HS and 99 healthy controls were included. The medical records and laboratory findings of the participants were reviewed retrospectively. Patients and control group neutrophil, lymphocyte, monocyte, and platelet counts, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR), mean platelet volume (MPV), platelet distribution width (PDW) and red cell distribution width coefficient of variation (RDW), SII and SIRI were compared.
Results:
The patient and control groups differed significantly concerning CRP, neutrophil count, lymphocyte count, monocytes count, platelet count, PLR, and MHR (p<0.05), whereas the mean of MPV and NLR did not show a significant difference in control individuals. SII and SIRI were significantly higher in patients with HS than in controls (p=0.005, p<0.001). Correlation analyses of SII and SIRI with each other and CRP were performed. It was determined that SIRI had a moderate correlation with CRP (r=0. 346, p<0.001). The correlation between SII and CRP was low (r=0.256, p<0.001). In addition, we analyzed the correlation between SII and SIRI and we determined a high level of correlation (r=0.675, p<0.001).
Conclusions:
Our study has objectively demonstrated that SII and SIRI are more reliable biomarkers than other inflammation parameters in HS patients. Thus, SII and SIRI would be used to evaluate treatment response and follow-up in HS as new indicators.
More Related Videos
09:11Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
Published on: February 14, 2021
10:21Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
