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Updated: Jul 13, 2025

Mutagenesis and Functional Selection Protocols for Directed Evolution of Proteins in E. coli
Published on: March 16, 2011
Michael L Wong1,2, Carol E Cleland3, Daniel Arend3
1Earth and Planets Laboratory, Carnegie Institution for Science, Washington, DC 20015.
A new law, the "law of increasing functional information," is proposed to explain how complex systems evolve. This law suggests that systems evolve when many configurations are selected for specific functions, driving increasing complexity.
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