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Prognostic factors in patients with cerebral sinus venous thrombosis presenting with hemorrhage and papilledema

Ayşegül Şeyma Sarıtaş1, Melike Batum1, Ceyla Ataç2

  • 1Celal Bayar University Neurology Department Manisa, Turkey.

Clinical Neurology and Neurosurgery
|October 16, 2023
PubMed

Insights

This study identified key thromboinflammatory markers predicting hemorrhage and papilledema in cerebral sinus vein thrombosis (CSVT) patients. Evaluating these markers aids in assessing CSVT prognosis and risk factors.

Area of Science:

  • Neurology
  • Hematology
  • Immunology

Background:

  • Cerebral sinus vein thrombosis (CSVT) pathogenesis and prognosis are linked to thromboinflammation.
  • Understanding thromboinflammatory markers is crucial for managing CSVT.

Purpose of the Study:

  • To compare thromboinflammatory parameters in CSVT patients versus healthy controls.
  • To analyze these parameters in CSVT subgroups based on hemorrhage and papilledema presence.
  • To identify predictors of hemorrhage and papilledema in CSVT.

Main Methods:

  • Retrospective comparison of thromboinflammatory markers in 88 CSVT patients and 80 controls.
  • Analysis of CSVT subgroups: with/without hemorrhage (35/53) and with/without papilledema (52/36).
  • Univariate and multivariate analyses to determine risk factors for hemorrhage and papilledema.

Main Results:

  • Significant hemorrhage risk factors in CSVT: low hematocrit (<30.2%), low mean platelet volume (≤8.9 fL), high neutrophil count (>5600), and high hsCRP (>9 mg/L).
  • Key papilledema risk factors in CSVT: younger age (≤49), vomiting, blurred vision, high HDL (>47 mg/dL), and high D-dimer (>178 ng/mL).

Conclusions:

  • Serum thromboinflammatory parameters are critical for predicting CSVT prognosis.
  • Demographic characteristics and neurological findings also play a significant role in CSVT risk assessment.
Abstract

Keywords:
Cerebral sinus vein thrombosisInflammationThromboinflammatory parameters

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