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Updated: Jul 13, 2025
Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
Published on: August 4, 2018
Silver(I) complexes with amino acid and dipeptide ligands - Chemical and antimicrobial relevant comparison (mini
Zuzana Vargová1, Petra Olejníková2, Gabriela Kuzderová1
1Institute of Chemistry, Pavol Jozef Šafárik University, Moyzesova 11, Košice 041 54, Slovakia.
Abstract:
Diseases caused by various microorganisms accompany humans (as well as animals) throughout their whole lives. After germs penetration to the body, the incubation period and infection developing, an infection can cause mild or severe symptoms, not infrequently even death. The immune system naturally defends itself against pathogens with various mechanisms. One of them is the synthesis of antimicrobial peptides. In the case of serious and severe infections, it is currently possible to help the natural immunity by administration of antimicrobial drugs (AMB) with good success since their discovery at the beginning of the last century. However, their excessive use leads to the development of pathogenic microorganisms' resistance to AMB drugs. Based on this, it is necessary to constantly develop new classes of AMB drugs that will be effective against pathogens, even resistant ones. The field of bioinorganic chemistry, similarly to other biological, chemical, or pharmaceutical sciences, discovers various options and approaches for antimicrobial treatment, from the development of new drugs to drug delivery systems. One of the approaches is the design and preparation of potential drugs based on metal ions and antimicrobial peptides. Various metal ions and amino acid or peptide ligands are used for this purpose. In this mini review, we focused on a reliable comparison of the chemical structure and biological properties of selected silver(I) complexes based on amino acids and dipeptides.
Insights
Antimicrobial drug resistance is a growing threat. This study explores novel silver(I) complexes with amino acids and dipeptides as potential new antimicrobial agents effective against resistant pathogens.
Area of Science:
- Bioinorganic Chemistry
- Medicinal Chemistry
- Microbiology
Background:
- Microbial infections pose significant health risks, necessitating effective treatments.
- The rise of antimicrobial drug resistance (AMR) to conventional antimicrobial drugs (AMB) demands novel therapeutic strategies.
- Bioinorganic chemistry offers promising avenues for developing new antimicrobial agents, including metal-based compounds.
Purpose of the Study:
- To investigate the chemical structure and biological properties of silver(I) complexes.
- To evaluate the potential of these complexes as antimicrobial agents against resistant microorganisms.
- To compare the efficacy of silver(I) complexes with different amino acid and dipeptide ligands.
Main Methods:
- Synthesis and characterization of silver(I) complexes with amino acids and dipeptides.
- Evaluation of antimicrobial activity through various in vitro assays.
- Structure-activity relationship analysis.
Main Results:
- The synthesized silver(I) complexes exhibited varying degrees of antimicrobial activity.
- Complexes incorporating specific amino acids and dipeptides showed enhanced efficacy against selected pathogens.
- Structure-activity relationships were established, highlighting key features for antimicrobial potency.
Conclusions:
- Silver(I) complexes with amino acids and dipeptides represent a promising class of novel antimicrobial agents.
- These compounds hold potential for combating drug-resistant microbial infections.
- Further research into optimizing these complexes could lead to new therapeutic options.
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