Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Calcium antagonists in heart failure?].

H Drexler, H Just

    Klinische Wochenschrift
    |October 15, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Calcium antagonists show mixed results in heart failure treatment. Newer, more selective agents may benefit patients with coronary artery disease and hypertension, but verapamil is not recommended for severe heart failure.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Basal cell carcinoma risk and solar UV exposure in occupationally relevant anatomic sites: do histological subtype, tumor localization and Fitzpatrick phototype play a role? A population-based case-control study.

    Journal of occupational medicine and toxicology (London, England)·2020
    Same author

    [Changes to the Law on Occupational Diseases and Consequences for Medical Assessment].

    Pneumologie (Stuttgart, Germany)·2020
    Same author

    Impact of physiologically relevant temperatures on dermal absorption of active substances - an ex-vivo study in human skin.

    Toxicology in vitro : an international journal published in association with BIBRA·2020
    Same author

    [Rare occupational diseases].

    Der Internist·2020
    Same author

    Evaluation of urinary selenium as a biomarker of human occupational exposure to elemental and inorganic selenium.

    International archives of occupational and environmental health·2019
    Same author

    Is ultraviolet exposure acquired at work the most important risk factor for cutaneous squamous cell carcinoma? Results of the population-based case-control study FB-181.

    The British journal of dermatology·2017

    Area of Science:

    • Cardiology
    • Pharmacology

    Context:

    • Calcium antagonists (CAs) have shown beneficial acute hemodynamic effects in heart failure (HF).
    • However, their use in HF remains controversial due to potential negative inotropic effects.
    • Autonomic reflexes modulate direct effects of CAs, influencing their clinical utility.

    Purpose:

    • To evaluate the role and safety of calcium antagonists in managing heart failure.
    • To compare the effects of different calcium antagonists on myocardial contractility and hemodynamics.
    • To assess the potential benefits of newer, vasoselective calcium antagonists in heart failure.

    Summary:

    • Direct negative inotropic effects of CAs can be counterbalanced by baroreceptor-mediated reflexes, especially with nifedipine and diltiazem.
    • Verapamil may cause significant depression of contractility, making it unsuitable for severe heart failure.

    Related Experiment Videos

  • Newer vasoselective CAs like nisoldipine and felodipine offer pronounced arterial vasodilation with minimal myocardial effects, potentially benefiting HF patients with comorbidities.

    • Impact:

    • Newer calcium antagonists may be advantageous for heart failure patients with coronary artery disease and hypertension.
    • Preliminary data suggest potential long-term benefits in selected heart failure patients.
    • Verapamil should be avoided in severe heart failure due to the risk of left ventricular (LV) function deterioration.