Related Experiment Video
Updated: Jul 13, 2025
Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
Published on: February 10, 2023
CAAStools: a toolbox to identify and test Convergent Amino Acid Substitutions
Fabio Barteri1,2, Alejandro Valenzuela1,2, Xavier Farré3
1IBE, Institute of Evolutionary Biology (UPF-CSIC), Department of Medicine and Life Sciences, Universitat Pompeu Fabra. C. Doctor Aiguader 88, Barcelona 08003, Spain.
Motivation:
Coincidence of Convergent Amino Acid Substitutions (CAAS) with phenotypic convergences allow pinpointing genes and even individual mutations that are likely to be associated with trait variation within their phylogenetic context. Such findings can provide useful insights into the genetic architecture of complex phenotypes.
Results:
Here we introduce CAAStools, a set of bioinformatics tools to identify and validate CAAS in orthologous protein alignments for predefined groups of species representing the phenotypic values targeted by the user.
Availability And Implementation:
CAAStools source code is available at http://github.com/linudz/caastools, along with documentation and examples.
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