Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

NONLIN84/PCNONLIN: software for the statistical analysis of nonlinear models.

D L Weiner

    Methods and Findings in Experimental and Clinical Pharmacology
    |October 1, 1986
    PubMed
    Summary

    A new software package, NONLIN84, simplifies the analysis of nonlinear and pharmacokinetic models. It offers enhanced features over NONLIN77 and includes extensive model libraries for easier use.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Mannan-binding lectin enhances susceptibility to visceral leishmaniasis.

    Infection and immunity·2001
    Same author

    Cardiac toxicity of intravenous terbutaline for the treatment of severe asthma in children: a prospective assessment.

    The Journal of pediatrics·2000
    Same author

    Serum amyloid A predicts early mortality in acute coronary syndromes: A TIMI 11A substudy.

    Journal of the American College of Cardiology·2000
    Same author

    Analytical evaluation of particle-enhanced immunonephelometric assays for C-reactive protein, serum amyloid A and mannose-binding protein in human serum.

    Annals of clinical biochemistry·1998
    Same author

    A forecasting approach to accelerate drug development.

    Statistics in medicine·1998
    Same author

    C-reactive protein is a potent predictor of mortality independently of and in combination with troponin T in acute coronary syndromes: a TIMI 11A substudy. Thrombolysis in Myocardial Infarction.

    Journal of the American College of Cardiology·1998

    Area of Science:

    • Pharmacometrics
    • Computational Biology
    • Statistical Modeling

    Background:

    • Nonlinear models are crucial for analyzing complex biological systems, particularly in pharmacokinetics.
    • Existing software like NONLIN77 had limitations in usability and scope.
    • Advancements in computational power necessitate updated analytical tools.

    Purpose of the Study:

    • To introduce NONLIN84, a new software package for general nonlinear model analysis.
    • To improve upon the capabilities and user-friendliness of previous versions.
    • To provide accessible libraries of pharmacokinetic models for researchers.

    Main Methods:

    • Development of the NONLIN84 software package.
    • Implementation of advanced estimation techniques, including maximum likelihood estimation with iterative reweighting.

    Related Experiment Videos

  • Inclusion of comprehensive libraries of pharmacokinetic models.
  • Development of a companion program, PCNONLIN, for microcomputer users.

    • Main Results:

    • NONLIN84 offers improved ease of use compared to NONLIN77.
    • The software supports a broader range of estimation problems.
    • Extensive pharmacokinetic model libraries are integrated and easily accessible.
    • PCNONLIN provides similar functionality on DOS-based microcomputers.

    Conclusions:

    • NONLIN84 represents a significant advancement in the analysis of nonlinear and pharmacokinetic models.
    • The software enhances research efficiency through improved usability and features.
    • Accessible model libraries and microcomputer compatibility broaden its application.