Related Experiment Video

Updated: Jul 13, 2025

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity
09:38

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity

Published on: January 31, 2025

442

Intermittent negative pressure therapy in patients with no-option chronic limb-threatening ischemia

Shatlyk Yagshyyev1, Phillip Hausmann1, Yi Li1

  • 1Department of Vascular Surgery, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Germany.

VASA. Zeitschrift Fur Gefasskrankheiten
|October 17, 2023
PubMed

Insights

Intermittent negative pressure (INP) therapy significantly improved skin perfusion and reduced rest pain in patients with critical limb ischemia (CLTI) who had no revascularization options. This therapy shows potential for treating these severe cases.

Area of Science:

  • Vascular Medicine
  • Biomedical Engineering
  • Regenerative Medicine

Background:

  • Critical limb ischemia (CLTI) poses a significant challenge, especially for patients deemed "no-option" for revascularization.
  • Foot microcirculation is a key indicator of tissue viability and therapeutic response in CLTI.
  • Assessing novel therapeutic interventions for improving microcirculation in CLTI is crucial.

Purpose of the Study:

  • To evaluate the impact of intermittent negative pressure (INP) therapy on foot microcirculation in no-option CLTI patients.
  • To assess changes in skin perfusion parameters including oxygen saturation, hemoglobin, and flow.
  • To correlate microcirculatory changes with clinical outcomes such as rest pain reduction.

Main Methods:

  • A cohort of 19 no-option CLTI patients received home-based INP therapy (1 hour, twice daily).
  • Microcirculation was measured using laser Doppler flowmetry and white light spectrometry (O2C™) at baseline, 6 weeks, and 3 months.
  • Key parameters assessed included oxygen saturation (sO2), relative hemoglobin (rHb), and flow (AU).

Main Results:

  • Significant improvement in skin oxygen saturation (sO2) was observed at 6 weeks (p=0.004).
  • While sO2 slightly decreased at 3 months, perfusion remained higher than baseline.
  • No significant changes were noted in flow (AU) or hemoglobin (AU), but rest pain was significantly reduced (p=0.005).

Conclusions:

  • INP therapy demonstrates a significant positive effect on skin perfusion in no-option CLTI patients within 6 weeks.
  • The observed improvements suggest INP therapy holds therapeutic potential for managing critical limb ischemia.
  • INP therapy may offer a viable treatment option for patients with limited conventional therapeutic choices.

Keywords:
FlowOxTMchronic limb-threating ischemiaintermittent negative pressuremicroperfusionno-option patientsoxygen to see (O2C)

More Related Videos

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism09:31

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

Published on: February 14, 2022

2.1K
Vascular Occlusion Training for Inclusion Body Myositis: A Novel Therapeutic Approach09:01

Vascular Occlusion Training for Inclusion Body Myositis: A Novel Therapeutic Approach

Published on: June 5, 2010

14.2K

Related Concept Videos

Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
11
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
12
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
11
Mechanical Ventilation III: Noninvasive Ventilation01:23

Mechanical Ventilation III: Noninvasive Ventilation

Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation...
134
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
14
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
10