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Non-coding RNA regulation of macrophage function in asthma

Chunyan Tian1, Jiawei Gao2, Liuxin Yang2

  • 1Heilongjiang University of Chinese Medicine, Harbin 150040, China; Department of Respiratory Medicine, The First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, China.

Cellular Signalling
|October 17, 2023
PubMed

Insights

Macrophages play a key role in asthma pathogenesis. Non-coding RNAs (ncRNAs) regulate these macrophages, offering potential new asthma treatments by modulating immune responses and airway remodeling.

Area of Science:

  • Immunology
  • Respiratory Medicine
  • Molecular Biology

Background:

  • Asthma is a chronic respiratory disease characterized by airway inflammation and remodeling.
  • Macrophages are critical innate immune cells in the airways, involved in various immune functions relevant to asthma.
  • Non-coding RNAs (ncRNAs) are increasingly recognized for their regulatory roles in asthma pathogenesis.

Conclusions:

  • Macrophages are key players in asthma, influenced by ncRNAs.
  • ncRNA-mediated regulation of macrophages offers novel therapeutic strategies for asthma.
  • Targeting ncRNA-macrophage interactions holds potential for effective asthma treatment.
Keywords:
AsthmaInflammationMacrophageNon-coding RNATherapy

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