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Pulmonary function after lobectomy in children: a systematic review and meta-analysis
Chenyu Liu1, Jie Liu1, Miao Yuan1
1Department of Pediatric Surgery, Sichuan University West China Hospital, Chengdu, Sichuan, China.
BMJ Paediatrics Open
|October 17, 2023
Summary
Pediatric lobectomy generally results in good pulmonary function. Young children with congenital lung malformations (CLM) undergoing lobectomy show normal lung function, unaffected by surgery timing.
Area of Science:
- Pediatric Pulmonology
- Thoracic Surgery
- Evidence-Based Medicine
Background:
- Pulmonary function changes after pediatric lobectomy remain debated.
- Systematic review and meta-analysis are needed to clarify the impact of lobectomy on children's lung function.
Approach:
- Searched PubMed, Embase, and Web of Science (1946-2022).
- Extracted FEV1, FVC, FEV1/FVC, and TLC.
- Conducted subgroup analyses for congenital lung malformations (CLM) and age at surgery (<1 year).
Key Points:
- Meta-analysis of 10 studies (5302 initial articles) revealed mild obstructive ventilatory disorder post-lobectomy.
- Children with CLM undergoing lobectomy demonstrated normal pulmonary function.
- Surgery timing did not significantly impact pulmonary function in CLM patients.
Conclusions:
- Overall pulmonary function in children post-lobectomy is favorable.
- Surgeons can be reassured regarding the impact of lung surgery on pediatric pulmonary function, especially for CLM cases.
Keywords:
Adolescent Health
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