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Updated: Jul 13, 2025

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A renaissance for YES in cancer

Marjorie Lapouge1, Sylvain Meloche2,3,4

  • 1Institute for Research in Immunology and Cancer, Montreal, QC, Canada.

Oncogene
|October 17, 2023
PubMed

Insights

Emerging research highlights the significant role of YES signaling in cancer development, progression, and treatment resistance. Targeting YES offers a promising therapeutic strategy for specific cancer subtypes, despite current challenges.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Signaling

Background:

  • SRC-family tyrosine kinases are crucial in cancer, with SRC being extensively studied.
  • Emerging evidence implicates YES signaling in key oncogenic processes like transformation, tumor growth, metastasis, and therapy resistance.

Purpose of the Study:

  • To review the critical role of YES signaling in cancer.
  • To discuss the challenges in developing effective YES-targeted therapies.

Main Methods:

  • Literature review of preclinical and clinical studies on YES signaling in cancer.

Main Results:

  • Dysregulated YES expression/activity is common in human cancers.
  • YES activity correlates with poor patient prognosis.
  • YES signaling contributes to tumor growth, metastasis, and drug resistance.

Conclusions:

  • YES is a significant factor in oncogenesis and cancer progression.
  • Targeting YES presents a viable therapeutic avenue for specific cancers.
  • Translating preclinical findings into clinical YES-targeted therapies faces challenges.

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