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Updated: Jul 13, 2025
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Published on: May 30, 2012
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p63: a crucial player in epithelial stemness regulation
Yanan Li1,2, Sara Giovannini1, Tingting Wang2
1Department of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133, Rome, Italy.
Oncogene
|October 17, 2023
Summary
The transcription factor p63 is crucial for epithelial stem cell (ESC) self-renewal and differentiation. This review details p63
Area of Science:
- Cell Biology
- Developmental Biology
- Molecular Biology
Background:
- Epithelial tissue homeostasis relies on epithelial stem cells (ESCs).
- p63 is a key transcription factor and marker for ESCs, essential for epithelial development.
- p63 regulates genes involved in cell survival, self-renewal, migration, differentiation, and epithelial-to-mesenchymal transition.
Purpose of the Study:
- To review the multifaceted role of p63 in regulating epithelial stemness.
- To explore the differential expression and functions of p63 isoforms (TAp63 and ΔNp63).
- To summarize signaling pathways that modulate p63 isoforms and their downstream effects on stemness.
Main Methods:
- Literature review of studies on p63 function in epithelial stem cells.
- Analysis of p63 isoform expression patterns in normal tissues and tumors.
- Synthesis of current knowledge on p63-mediated signaling pathways.
Main Results:
- p63 isoforms exhibit distinct activities crucial for ESC self-renewal, differentiation, proliferation, and senescence.
- Differential expression of TAp63 and ΔNp63 isoforms is observed in various epithelial tissues and cancers.
- p63 plays a significant role in both normal epithelial development and the pathogenesis of epithelial cancers.
Conclusions:
- p63 is a critical regulator of epithelial stemness, with distinct isoforms contributing to diverse cellular processes.
- Understanding p63 isoform function and regulation is vital for insights into epithelial development and cancer biology.
- Further research into p63-mediated signaling pathways can reveal therapeutic targets for epithelial-derived cancers.
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