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A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation
Published on: June 10, 2020
Association Between Monocyte-to-Lymphocyte Ratio and Hematoma Progression After Cerebral Contusion
Huajun Zhang1,2, Xiaochun Duan1, Yimiao Zhang3
1Department of Neurosurgery, Affiliated Hospital of Yangzhou University, 45 Taizhou Road, Guangling District, Yangzhou City, Jiangsu Province, China.
Background:
The objective of this research was to examine the impact of the monocyte-to-lymphocyte ratio (MLR) on the advancement of hematoma after cerebral contusion.
Methods:
The clinical information and laboratory test findings of people with cerebral contusion were retrospectively analyzed. Using the tertiles of MLR, the study participants were categorized into three groups, enabling the evaluation of the correlation between MLR and the advancement of hematoma after cerebral contusion.
Results:
Among the cohort of patients showing progression, MLR levels were significantly higher compared with the nonprogress group (P < 0.001). The high MLR group had a significantly higher proportion of patients with hematoma progression compared with the medium and low MLR groups. However, the medium MLR group had a lower proportion of patients with hematoma progression compared with the low MLR group. High MLR levels were independently linked to a higher risk of hematoma progression (Odds Ratio 3.546, 95% Confidence Interval 1.187-10.597, P = 0.024). By incorporating factors such as Glasgow Coma Scale score on admission, anticoagulant/antiplatelet therapy, white blood cell count, and MLR into the model, the predictive performance of the model significantly improved (area under the curve 0.754).
Conclusions:
Our study suggests that MLR may serve as a potential indicator for predicting the progression of hematoma after cerebral contusion. Further research is necessary to investigate the underlying pathological and physiological mechanisms that contribute to the association between MLR and the progression of hematoma after cerebral contusion and to explore its clinical implications.
Insights
The monocyte-to-lymphocyte ratio (MLR) may predict hematoma progression after cerebral contusion. Higher MLR levels are linked to increased risk, suggesting MLR as a potential prognostic indicator in clinical practice.
Area of Science:
- Neuroscience
- Immunology
- Hematology
Background:
- Cerebral contusion can lead to hematoma formation and expansion.
- Predictive markers for hematoma progression are crucial for patient management.
Purpose of the Study:
- To investigate the association between the monocyte-to-lymphocyte ratio (MLR) and hematoma progression following cerebral contusion.
- To evaluate MLR as a potential predictor of hematoma advancement.
Main Methods:
- Retrospective analysis of clinical data and laboratory findings in patients with cerebral contusion.
- Categorization of patients into tertiles based on MLR levels.
- Statistical analysis to determine the correlation between MLR and hematoma progression.
Main Results:
- Significantly higher MLR levels were observed in patients with hematoma progression compared to those without (P < 0.001).
- A higher proportion of patients with hematoma progression was found in the high MLR group.
- High MLR was independently associated with an increased risk of hematoma progression (OR 3.546, P = 0.024).
- Incorporating MLR improved the predictive model's performance (AUC 0.754).
Conclusions:
- MLR shows potential as a predictive indicator for hematoma progression after cerebral contusion.
- Further research is warranted to elucidate the mechanisms underlying this association and its clinical utility.
