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The Isolation and Culture of Primary Epicardial Cells Derived from Human Adult and Fetal Heart Specimens
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Epicardial Adipose Tissue: a Potential Therapeutic Target for Cardiovascular Diseases

Wenxi Fang1,2, Saiyang Xie1,2, Wei Deng3,4

  • 1Department of Cardiology, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan, 430060, People's Republic of China.

Journal of Cardiovascular Translational Research
|October 17, 2023
PubMed

Insights

Epicardial adipose tissue (EAT), a type of visceral fat, is increasingly recognized as a significant factor in cardiovascular disease (CVD) risk. Understanding EAT

Area of Science:

  • Cardiology
  • Endocrinology
  • Anatomy

Background:

  • Cardiovascular disease (CVD) is a leading global health concern, particularly with an aging population.
  • Obesity is an independent risk factor for CVD, with visceral adipose tissue (VAT) gaining research focus.
  • Epicardial adipose tissue (EAT), a specific type of VAT, possesses unique characteristics relevant to CVD.

Purpose of the Study:

  • To systematically review the physiological characteristics of EAT.
  • To describe the evaluation methods for EAT.
  • To emphasize EAT's role and therapeutic strategies in managing CVD.

Main Methods:

  • Systematic literature review.
  • Analysis of physiological and anatomical studies on EAT.
  • Review of clinical guidelines and research on EAT in CVD.

Main Results:

  • EAT exhibits distinct physiological properties compared to other adipose tissues.
  • Various imaging and biochemical methods can evaluate EAT.
  • EAT is implicated in the pathogenesis and progression of CVD.

Conclusions:

  • EAT plays a crucial role in cardiovascular health and disease.
  • Further research into EAT's function and targeted therapies is warranted.
  • EAT evaluation and management should be considered in CVD patient care.

Keywords:
Cardiovascular diseaseEpicardial adipose tissueEvaluationTreatment measures

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