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Nanodelivery Systems as a Novel Strategy to Overcome Treatment Failure of Cancer
Shi He1, Xinyu Gou1, Shuheng Zhang2
1Department of Neurosurgery and Institute of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, China.
Abstract:
Despite the tremendous progress in cancer treatment in recent decades, cancers often become resistant due to multiple mechanisms, such as intrinsic or acquired multidrug resistance, which leads to unsatisfactory treatment effects or accompanying metastasis and recurrence, ultimately to treatment failure. With a deeper understanding of the molecular mechanisms of tumors, researchers have realized that treatment designs targeting tumor resistance mechanisms would be a promising strategy to break the therapeutic deadlock. Nanodelivery systems have excellent physicochemical properties, including highly efficient tissue-specific delivery, substantial specific surface area, and controllable surface chemistry, which endow nanodelivery systems with capabilities such as precise targeting, deep penetration, responsive drug release, multidrug codelivery, and multimodal synergy, which are currently widely used in biomedical researches and bring a new dawn for overcoming cancer resistance. Based on the mechanisms of tumor therapeutic resistance, this review summarizes the research progress of nanodelivery systems for overcoming tumor resistance to improve therapeutic efficacy in recent years and offers prospects and challenges of the application of nanodelivery systems for overcoming cancer resistance.
Insights
Nanodelivery systems offer a promising strategy to overcome cancer multidrug resistance by enabling precise targeting and controlled drug release. This approach enhances therapeutic efficacy and combats tumor recurrence, addressing critical challenges in cancer treatment.
Area of Science:
- Biomedical Engineering
- Oncology
- Nanotechnology
Background:
- Cancer treatment faces significant challenges due to multidrug resistance (MDR), leading to metastasis, recurrence, and treatment failure.
- Tumor resistance mechanisms necessitate novel therapeutic strategies to improve treatment outcomes.
- Understanding tumor molecular mechanisms is crucial for developing effective resistance-targeting treatments.
Purpose of the Study:
- To review recent advancements in nanodelivery systems for overcoming tumor therapeutic resistance.
- To summarize research progress in enhancing cancer treatment efficacy using nanocarriers.
- To discuss the prospects and challenges of nanodelivery systems in combating cancer resistance.
Main Methods:
- Comprehensive literature review of nanodelivery systems applied to cancer resistance.
- Analysis of nanodelivery system properties relevant to overcoming tumor resistance mechanisms.
- Synthesis of research findings on nanocarrier-based strategies for improved therapeutic effects.
Main Results:
- Nanodelivery systems exhibit properties like tissue-specific delivery, large surface area, and controllable chemistry.
- These systems enable precise targeting, deep tumor penetration, responsive drug release, and multidrug co-delivery.
- Nanodelivery systems demonstrate significant potential in overcoming various cancer resistance mechanisms.
Conclusions:
- Nanodelivery systems represent a powerful tool for overcoming cancer resistance and improving treatment efficacy.
- Further research into nanocarrier design and application is essential to fully realize their therapeutic potential.
- Addressing the challenges associated with nanodelivery systems will pave the way for clinical translation in oncology.
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