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Paramyxoviruses: Pathogenesis, Vaccines, Antivirals, and Prototypes for Pandemic Preparedness

W Paul Duprex1,2, Rebecca Ellis Dutch3

  • 1Center for Vaccine Research.

The Journal of Infectious Diseases
|October 18, 2023
PubMed

Insights

Paramyxoviruses, including measles and Nipah viruses, pose pandemic threats due to high transmission and fatality rates. This review identifies research gaps and proposes prototype pathogens for studying this virus family.

Area of Science:

  • Virology
  • Infectious Diseases
  • Public Health

Background:

  • The Paramyxoviridae family encompasses significant human pathogens like measles virus and Nipah virus, alongside poorly understood emerging viruses.
  • Paramyxoviruses exhibit high human-to-human transmission and high case fatality rates, indicating substantial pandemic potential.

Conclusions:

  • Paramyxoviruses represent a significant public health concern due to their diverse pathogenic potentials.
  • Addressing identified research gaps is crucial for preparedness against known and unknown Paramyxoviruses.
  • The proposed prototype pathogens offer valuable models for advancing research on the Paramyxoviridae family.
Keywords:
pandemic preparednessparamyxovirusprototype pathogenszoonosis

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