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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
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Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Limited Cutaneous Scleroderma: A Case Report.

Manvi Marathe1, Shweta Borkar2

  • 1Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.

Cureus
|October 18, 2023
PubMed
Summary

Localised scleroderma, or morphea, is a connective tissue disease causing skin hardening. Early management is crucial to prevent potential complications and organ involvement.

Keywords:
crest syndromecutaneous sclerosismorpheasclerodermavitiligo

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Area of Science:

  • Rheumatology
  • Dermatology
  • Internal Medicine

Background:

  • Scleroderma is a rare connective tissue disease characterized by skin hardening and potential organ damage.
  • Two main forms exist: localised scleroderma (morphea) and systemic sclerosis.
  • Localised scleroderma typically affects the skin and underlying tissues, often with a milder course.

Observation:

  • The etiology of localised scleroderma remains largely unknown.
  • Emerging research indicates variable severity and potential for organ involvement in localised scleroderma.
  • High morbidity associated with localised scleroderma necessitates prompt intervention.

Findings:

  • This article details the primary management strategies for localised scleroderma.
  • Focus is placed on early treatment to mitigate disease progression and complications.
  • Understanding the nuances of localised scleroderma aids in effective patient care.

Implications:

  • Early and comprehensive management of localised scleroderma can significantly improve patient outcomes.
  • Further research into the causes and mechanisms of localised scleroderma is warranted.
  • This review provides essential insights for clinicians managing patients with this condition.