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Ara-C syndrome during low-dose continuous infusion therapy.
Medical and Pediatric Oncology
|January 1, 1986
Summary
Low-dose cytosine arabinoside (ara-C) therapy for acute nonlymphocytic leukemia can cause the "ara-C syndrome." This syndrome includes fever, peritonitis, pericarditis, and rash, previously seen only with higher doses.
Area of Science:
- Oncology
- Hematology
- Pharmacology
Background:
- Cytosine arabinoside (ara-C) is a chemotherapy agent used in treating acute leukemias.
- The
Observation:
- Four patients with acute nonlymphocytic leukemia experienced symptoms of the
Findings:
- Continuous infusions of low-dose cytosine arabinoside (20 mg/m2/d) were associated with the development of the
Implications:
- The