Recent advances on cyclodepsipeptides: biologically active compounds for drug research

Area of Science:

• Natural Product Chemistry
• Microbiology
• Medicinal Chemistry

Background:

• Cyclodepsipeptides are natural products formed from hydroxy and amino acids.
• These compounds are produced by fungi and bacteria.
• Many cyclodepsipeptides exhibit potent bioactivities, including antitumor, antifungal, antiviral, antimalarial, and antitrypanosomal effects.

Purpose of the Study:

• To review recent literature (2010-2022) on cyclodepsipeptides from fungal and bacterial sources.
• To consolidate knowledge on the structural diversity of these compounds.
• To document the biological activities and sources of non-marine cyclodepsipeptides.

Main Methods:

• Literature search of scientific databases for relevant publications from 2010 to 2022.
• Analysis of identified articles for structural information and biological activities.
• Exclusion of cyclodepsipeptides derived from marine organisms.

Main Results:

• Compilation of numerous cyclodepsipeptides isolated from fungi and bacteria.
• Detailed characterization of their structural features, including amide and ester linkages.
• Summary of a wide spectrum of reported biological activities.

Conclusions:

• Fungal and bacterial cyclodepsipeptides represent a rich source of bioactive molecules.
• Continued research into these compounds may yield novel therapeutic agents.
• This review provides a comprehensive overview of recent progress in the field.