Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selenium-75: a potential source for use in high-activity brachytherapy irradiators.

K J Weeks, R J Schulz

    Medical Physics
    |September 1, 1986
    PubMed
    Summary

    Researchers identified Selenium-75 (75Se) as a promising radioisotope to replace Iridium-192 (192Ir) in brachytherapy devices. This new isotope offers a longer half-life and lower gamma-ray energies for improved treatment.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Impact of opium on bladder cancer incidence: A systematic review and meta-analysis.

    Actas urologicas espanolas·2025
    Same author

    Long-term functional success and patient-reported outcomes after female one-stage buccal mucosal graft urethroplasty.

    Actas urologicas espanolas·2024
    Same author

    The future of radiation therapy.

    Journal of applied clinical medical physics·2021
    Same author

    Does the identification of seniors at risk (ISAR) score effectively select geriatric patients on emergency admission?

    Aging clinical and experimental research·2019
    Same author

    Analysis of cytopenia in geriatric inpatients.

    Zeitschrift fur Gerontologie und Geriatrie·2017
    Same author

    Nutraceuticals in cognitive impairment and Alzheimer's disease.

    Frontiers in pharmacology·2014

    Area of Science:

    • Medical Physics
    • Radiochemistry
    • Nuclear Medicine

    Background:

    • Iridium-192 (192Ir) is a commonly used radioisotope in afterloading brachytherapy devices.
    • There is a need for radioisotopes with longer half-lives and lower gamma-ray energies to improve brachytherapy efficacy and safety.
    • Current 192Ir sources have limitations in terms of handling and dose delivery precision.

    Purpose of the Study:

    • To identify and evaluate a high-specific-activity radioisotope as a potential replacement for 192Ir in brachytherapy.
    • To assess Selenium-75 (75Se) for its physical properties, production methods, and suitability for encapsulated sources.
    • To confirm the feasibility of using 75Se in high-activity afterloading brachytherapy devices.

    Main Methods:

    • Selection of potential radioisotopes based on desired characteristics (half-life, gamma-ray energy).

    Related Experiment Videos

  • Detailed characterization of the physical properties of Selenium-75 (75Se).
  • Development and fabrication of an encapsulated 75Se source for experimental validation.

    • Main Results:

    • Selenium-75 (75Se) was identified as a suitable candidate radioisotope.
    • The physical properties of 75Se align with the requirements for brachytherapy applications.
    • Fabricated encapsulated 75Se sources demonstrated the accuracy of initial calculations.

    Conclusions:

    • Selenium-75 (75Se) presents a viable alternative to Iridium-192 (192Ir) for afterloading brachytherapy.
    • The longer half-life and lower gamma-ray energies of 75Se offer potential advantages in brachytherapy.
    • Further studies and clinical trials are warranted to fully establish 75Se as a replacement radioisotope.