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Updated: Jul 13, 2025

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

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Prophylactic Absorbable Antibiotic Beads for High-risk, Implant-based Prepectoral Reconstruction.

Shahnur Ahmed¹, Jason T C Lee¹, Dylan Roth¹

¹From Division of Plastic Surgery, Indiana University School of Medicine, Indianapolis, Ind.

Plastic and Reconstructive Surgery. Global Open

|October 18, 2023

Summary

Prophylactic antibiotic beads may help reduce infection risk in high-risk breast reconstruction patients. This pilot study suggests absorbable antibiotic beads normalize infection rates in these cases.

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PRP as a New Approach to Prevent Infection: Preparation and In vitro Antimicrobial Properties of PRP

PRP as a New Approach to Prevent Infection: Preparation and In vitro Antimicrobial Properties of PRP

Published on: April 9, 2013

Area of Science:

Plastic Surgery
Infectious Disease Prevention
Biomaterials

Background:

Postmastectomy implant-based reconstruction faces high infection rates (up to 30%).
Systemic antibiotics lack proven benefit; novel strategies are needed.
Absorbable antibiotic beads are understudied in breast reconstruction, especially prepectoral.

Purpose of the Study:

To evaluate the efficacy of prophylactic absorbable calcium sulfate antibiotic beads.
To assess infection rates in high-risk, implant-based, prepectoral breast reconstruction.
To explore a novel application of antibiotic beads in plastic surgery.

Main Methods:

Retrospective review of 148 patients (2019-2022) undergoing prepectoral breast reconstruction.
Comparison between patients receiving antibiotic beads (n=15) and a control group (n=133).
Primary outcome: postoperative surgical site infection at 90 days.

Main Results:

Antibiotic bead group had a higher history of infection (66.7% vs 0%, P < 0.01).
Infection rates were 3.2% (bead group) vs 7.6% (control group), not statistically significant.
Antibiotic beads appeared to normalize infection incidence in high-risk patients.

Conclusions:

Absorbable antibiotic beads may be a viable option for infection prophylaxis in high-risk breast reconstruction.
This pilot study supports further investigation into antibiotic beads for prepectoral implant placement.
Novel use of prophylactic absorbable antibiotic beads in breast reconstruction is presented.