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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Glioma-associated mesenchymal stem cells.

Qing-Mei Kang1,2,3,4,5, Jun Wang1,3,4,5, Shi-Man Chen1,3,4,5

  • 1Department of Stem Cell and Regenerative Medicine, Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Chongqing, 400038, China.

Brain : a Journal of Neurology
|October 18, 2023
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Glioma-associated mesenchymal stem cells are crucial in tumor growth and progression. This review explores their origins, functions, and therapeutic potential for glioma treatment.

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central nervous systemgliomamesenchymal stem cellsmicroenvironment

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Area of Science:

  • Neuro-oncology
  • Cancer Stem Cell Biology
  • Tumor Microenvironment Research

Background:

  • Glioma-associated mesenchymal stem cells (GA-MSCs) are increasingly recognized as key players in the glioma microenvironment.
  • Their specific origins and multifaceted roles in tumor development remain incompletely understood.
  • Existing research highlights GA-MSCs' significant contributions to tumor proliferation, invasion, and angiogenesis.

Conclusions:

  • Further research into GA-MSCs is essential for advancing glioma treatment strategies.
  • Targeting GA-MSCs presents a promising therapeutic opportunity.
  • A deeper understanding of GA-MSCs can lead to improved patient outcomes.