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Development and Implementation of a Multi-Disciplinary Technology Enhanced Care Pathway for Youth and Adults with Concussion

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Cleveland Clinic Continuous-Flow Total Artificial Heart: Progress Report and Technology Update.

Taiyo Kuroda¹, Chihiro Miyagi¹, Anthony R Polakowski¹

¹From the Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)

|October 18, 2023

Summary

Cleveland Clinic

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Area of Science:

Biomedical Engineering
Cardiovascular Research

Background:

Development of the continuous-flow total artificial heart (CFTAH) is ongoing.
Previous CFTAH versions showed system reliability and optimal performance.

Purpose of the Study:

To report progress in the development of Cleveland Clinic's CFTAH.
To enhance CFTAH biocompatibility through design revisions.

Main Methods:

Design revisions focused on the right impeller, pump housing, and motor.
Computational fluid dynamics (CFD) analysis informed design updates.
In vitro and in vivo studies guided biocompatibility improvements.

Main Results:

A revised CFTAH version was successfully manufactured and tested.
Hemodynamic and pump parameters remained within intended ranges.
The updated CFTAH demonstrated acceptable biocompatibility.

Conclusions:

Cleveland Clinic's CFTAH shows continued reliable performance.
Satisfactory progress has been made in CFTAH development.