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Cleveland Clinic Continuous-Flow Total Artificial Heart: Progress Report and Technology Update
Taiyo Kuroda1, Chihiro Miyagi1, Anthony R Polakowski1
1From the Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|October 18, 2023
Summary
Cleveland Clinic
Area of Science:
- Biomedical Engineering
- Cardiovascular Research
Background:
- Development of the continuous-flow total artificial heart (CFTAH) is ongoing.
- Previous CFTAH versions showed system reliability and optimal performance.
Purpose of the Study:
- To report progress in the development of Cleveland Clinic's CFTAH.
- To enhance CFTAH biocompatibility through design revisions.
Main Methods:
- Design revisions focused on the right impeller, pump housing, and motor.
- Computational fluid dynamics (CFD) analysis informed design updates.
- In vitro and in vivo studies guided biocompatibility improvements.
Main Results:
- A revised CFTAH version was successfully manufactured and tested.
- Hemodynamic and pump parameters remained within intended ranges.
- The updated CFTAH demonstrated acceptable biocompatibility.
Conclusions:
- Cleveland Clinic's CFTAH shows continued reliable performance.
- Satisfactory progress has been made in CFTAH development.
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