Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

14
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
14
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

956
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
956
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

557
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
557
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

11
 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
11
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

2.7K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.7K
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

9
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs but also impacts other areas, such as the arms, thereby impairing overall circulation and organ function.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty deposits inside the arterial...
9

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Message From the Editors to Our Reviewers.

Neurology·2026
Same author

Comparing In-Person to Tele-Exercise High-Intensity Interval Training in Adults With Class II/III Obesity.

AACE endocrinology and diabetes·2026
Same author

Metabolic and Microvascular Risk Factors Associated With Brain Health in Type 1 Diabetes.

Annals of clinical and translational neurology·2026
Same author

Diabetic Peripheral Neuropathy May Be an Independent Risk Marker for Dementia and Cerebrovascular Disease.

Diabetes, obesity & metabolism·2026
Same author

Virtual vs In-Person Neurologic Ambulatory Care: A Case-Control Study of Subsequent Health Care Utilization.

Neurology·2026
Same author

Psychometric Properties of Ecological Momentary Assessment of Psychosocial Functioning in Adults With Complications Related to Type 1 Diabetes.

Canadian journal of diabetes·2026
Same journal

Key Considerations in Telestroke Program Management.

Continuum (Minneapolis, Minn.)·2026
Same journal

Neurology's Action Potential: Delivering on the Promise of Brain Health.

Continuum (Minneapolis, Minn.)·2026
Same journal

Erratum.

Continuum (Minneapolis, Minn.)·2026
Same journal

Management of Large Artery Atherosclerosis.

Continuum (Minneapolis, Minn.)·2026
Same journal

Thrombolysis, Thrombectomy, and Antithrombotic Therapy for Acute Ischemic Stroke.

Continuum (Minneapolis, Minn.)·2026
Same journal

Stroke in Children and Younger Adults.

Continuum (Minneapolis, Minn.)·2026
See all related articles

Related Experiment Video

Updated: Jul 13, 2025

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise
05:06

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise

Published on: July 14, 2023

1.7K

Diabetic Neuropathies.

Melissa A Elafros, Brian C Callaghan

    Continuum (Minneapolis, Minn.)
    |October 18, 2023
    PubMed
    Summary
    This summary is machine-generated.

    Diabetic neuropathies are increasing globally. Effective management involves glycemic control, addressing metabolic factors, and pain relief, crucial for preventing progression.

    More Related Videos

    Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies
    11:22

    Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies

    Published on: April 29, 2013

    13.2K
    Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
    09:39

    Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

    Published on: February 13, 2018

    9.6K

    Related Experiment Videos

    Last Updated: Jul 13, 2025

    Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise
    05:06

    Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise

    Published on: July 14, 2023

    1.7K
    Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies
    11:22

    Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies

    Published on: April 29, 2013

    13.2K
    Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
    09:39

    Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

    Published on: February 13, 2018

    9.6K

    Area of Science:

    • Neurology
    • Endocrinology
    • Diabetology

    Background:

    • The global prevalence of diabetes is rising, leading to an increased incidence of diabetic neuropathies.
    • Diabetic neuropathies stem from hyperglycemic effects on nerve fibers, with type 1 diabetes patients benefiting from glycemic control.
    • Type 2 diabetes involves additional factors like metabolic syndrome, necessitating comprehensive management strategies.

    Purpose of the Study:

    • To review the diagnosis and management of common neuropathies in diabetic patients.
    • To highlight the increasing global burden of diabetic neuropathies.
    • To discuss updated treatment guidelines for diabetic neuropathy pain.

    Main Methods:

    • Review of current literature and evidence-based guidelines.
    • Analysis of the pathophysiology of diabetic neuropathies.
    • Synthesis of diagnostic and management approaches.

    Main Results:

    • Distal symmetric polyneuropathy is the most common type, but autonomic and lumbosacral neuropathies carry significant risks.
    • Cardiovascular autonomic neuropathy is linked to increased mortality.
    • Updated treatments focus on pain management for distal symmetric polyneuropathy.

    Conclusions:

    • Accurate diagnosis of diabetic neuropathies is vital for preventing disease progression.
    • Current management strategies emphasize diabetes and metabolic risk factor control.
    • Pain management remains a key component in the absence of disease-modifying therapies.