Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

968
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
968
Cross-bridge Cycle01:26

Cross-bridge Cycle

117.6K
As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
117.6K
Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

2.0K
Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
2.0K
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

1.5K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.5K
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

924
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
924
Chemical Synapses01:26

Chemical Synapses

8.9K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
8.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy and safety of risdiplam in patients with type 1 spinal muscular atrophy: a 3-year open-label extension of the two-part, phase 2 FIREFISH trial.

The Lancet. Child & adolescent health·2026
Same author

Health economic evaluations of genomic newborn screening: Approaches by studies within the international consortium on newborn sequencing.

European journal of human genetics : EJHG·2026
Same author

A Validated Prognostic Score for Time to Loss of Ambulation in Patients With Duchenne Muscular Dystrophy.

Neurology·2026
Same author

Predicting Functional Decline in Duchenne Muscular Dystrophy: Advancing Trial Readiness and Patient Counseling.

Neurology·2026
Same author

The phenotypic spectrum and genetic determinants of severe spinal muscular atrophy in individuals with a single <i>SMN2</i> copy: an international retrospective observational study.

EClinicalMedicine·2026
Same author

Genomic newborn screening for actionable, sight-threatening eye diseases.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie·2026
Same journal

Key Considerations in Telestroke Program Management.

Continuum (Minneapolis, Minn.)·2026
Same journal

Neurology's Action Potential: Delivering on the Promise of Brain Health.

Continuum (Minneapolis, Minn.)·2026
Same journal

Erratum.

Continuum (Minneapolis, Minn.)·2026
Same journal

Management of Large Artery Atherosclerosis.

Continuum (Minneapolis, Minn.)·2026
Same journal

Thrombolysis, Thrombectomy, and Antithrombotic Therapy for Acute Ischemic Stroke.

Continuum (Minneapolis, Minn.)·2026
Same journal

Stroke in Children and Younger Adults.

Continuum (Minneapolis, Minn.)·2026
See all related articles

Related Experiment Video

Updated: Jul 13, 2025

Systemic Delivery of MicroRNA Using Recombinant Adeno-associated Virus Serotype 9 to Treat Neuromuscular Diseases in Rodents
06:51

Systemic Delivery of MicroRNA Using Recombinant Adeno-associated Virus Serotype 9 to Treat Neuromuscular Diseases in Rodents

Published on: August 10, 2018

7.7K

Spinal Muscular Atrophy.

Maryam Oskoui, Laurent Servais

    Continuum (Minneapolis, Minn.)
    |October 18, 2023
    PubMed
    Summary
    This summary is machine-generated.

    Spinal muscular atrophy (SMA) diagnosis and treatment have advanced significantly. Early intervention with supportive care and new FDA-approved therapies improves outcomes for individuals with SMN1 deletions.

    More Related Videos

    Dissection of the Transversus Abdominis Muscle for Whole-mount Neuromuscular Junction Analysis
    06:12

    Dissection of the Transversus Abdominis Muscle for Whole-mount Neuromuscular Junction Analysis

    Published on: January 11, 2014

    11.7K
    Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis ALS
    12:35

    Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis ALS

    Published on: March 17, 2012

    28.1K

    Related Experiment Videos

    Last Updated: Jul 13, 2025

    Systemic Delivery of MicroRNA Using Recombinant Adeno-associated Virus Serotype 9 to Treat Neuromuscular Diseases in Rodents
    06:51

    Systemic Delivery of MicroRNA Using Recombinant Adeno-associated Virus Serotype 9 to Treat Neuromuscular Diseases in Rodents

    Published on: August 10, 2018

    7.7K
    Dissection of the Transversus Abdominis Muscle for Whole-mount Neuromuscular Junction Analysis
    06:12

    Dissection of the Transversus Abdominis Muscle for Whole-mount Neuromuscular Junction Analysis

    Published on: January 11, 2014

    11.7K
    Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis ALS
    12:35

    Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis ALS

    Published on: March 17, 2012

    28.1K

    Area of Science:

    • Neurology
    • Genetics
    • Pediatrics

    Background:

    • Spinal muscular atrophy (SMA) is a genetic neuromuscular disorder caused by homozygous deletions of the SMN1 gene.
    • Newborn screening for SMA is expanding, but vigilance is required for early diagnosis in unscreened populations and for missed compound heterozygotes.

    Approach:

    • This article reviews the diagnostic assessment and treatment strategies for SMA.
    • It highlights the importance of supportive care, adaptive equipment, and pharmacologic interventions.

    Key Points:

    • FDA-approved therapies (nusinersen, onasemnogene abeparvovec, risdiplam) target survival motor neuron (SMN) protein levels.
    • Treatment efficacy is measured by event-free survival and motor function gains.
    • Earlier treatment initiation correlates with improved outcomes across all therapeutic approaches.

    Conclusions:

    • Advancements in SMA diagnosis and treatment have dramatically improved patient prognosis.
    • Optimized supportive care remains critical.
    • Further research is needed to understand the evolving natural history of SMA with new interventions.