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Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
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Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

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Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
924
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

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Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
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Neuromuscular Junction And Blockade01:29

Neuromuscular Junction And Blockade

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The site of chemical communication between a motor neuron and a muscle fiber is called the neuromuscular junction (NMJ). The end of the motor neuron at the NMJ divides into a cluster of synaptic end bulbs. The cytoplasm of these bulbs consists of synaptic vesicles enclosing acetylcholine molecules, the principal neurotransmitter released at the NMJ. The region opposite the synaptic bulb that ends in the muscle fiber is called the motor end plate, which has acetylcholine receptors. Within the...
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Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

493
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
493
Classification of Skeletal Muscle Relaxants01:28

Classification of Skeletal Muscle Relaxants

2.5K
Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
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Related Experiment Video

Updated: Jul 13, 2025

A Murine Model of Muscle Training by Neuromuscular Electrical Stimulation
08:24

A Murine Model of Muscle Training by Neuromuscular Electrical Stimulation

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Multidisciplinary Clinics in Neuromuscular Medicine.

Kelly Gwathmey, Terry D Heiman-Patterson

    Continuum (Minneapolis, Minn.)
    |October 18, 2023
    PubMed
    Summary

    Multidisciplinary care models improve outcomes for neuromuscular disorders by consolidating appointments. Telehealth options may overcome barriers like travel distance and visit duration, enhancing patient access and quality of life.

    Area of Science:

    • Neurology
    • Clinical Care Models
    • Rehabilitation Medicine

    Background:

    • Neuromuscular disorders (e.g., amyotrophic lateral sclerosis, muscular dystrophies) cause significant disability and extramuscular symptoms.
    • Traditional care models often involve fragmented appointments, increasing patient burden.
    • Multidisciplinary care offers a coordinated approach across medical disciplines and allied health professions.

    Purpose of the Study:

    • To evaluate the benefits of a neuromuscular multidisciplinary care model.
    • To identify potential improvements in patient outcomes, satisfaction, quality of life, and survival.
    • To explore the efficiency and cost-effectiveness of consolidated clinic visits.

    Main Methods:

    • The study focuses on the conceptual framework and goals of a multidisciplinary care model for neuromuscular disorders.

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  • It reviews potential benefits and barriers associated with this care delivery approach.
  • The potential role of telehealth in overcoming access barriers is considered.

    • Main Results:

    • Multidisciplinary clinics aim to enhance patient outcomes, satisfaction, quality of life, and survival.
    • While clinic operational costs are high, patient-specific cost savings are anticipated.
    • Barriers include travel distance and visit duration, which telehealth may mitigate.

    Conclusions:

    • Multidisciplinary care models show promise for improving the management of complex neuromuscular disorders.
    • Telehealth integration offers a potential solution to key accessibility barriers.
    • Further research is essential to establish the value and sustainability of these integrated care models.