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LIVER TRANSPLANTATION IN PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS: A MULTICENTRIC STUDY
Henrique de Aguiar Wiederkehr1, Julio Cesar Wiederkehr1,2, Mauro Rafael Da Igreja2
1Universidade Federal do Paraná, University Hospital, Liver Transplant Department, Curitiba (PR), Brazil.
Summary
Liver transplantation (LT) for primary sclerosing cholangitis (PSC) in Brazil shows good survival rates. PSC recurrence was observed in 8.1% of patients, with overall patient and graft survival rates exceeding 80% at five years.
Area of Science:
- Hepatology
- Transplant Surgery
- Autoimmune Diseases
Background:
- Primary sclerosing cholangitis (PSC) is a chronic liver disease with limited treatment options.
- Liver transplantation (LT) is the only curative therapy for advanced PSC.
- PSC accounts for 5% of adult LT indications, highlighting its significance in transplant centers.
Purpose of the Study:
- To evaluate the indications and outcomes of LT in patients with PSC.
- To assess patient and graft survival rates following LT for PSC.
- To analyze PSC recurrence post-transplantation in a Brazilian cohort.
Main Methods:
- A longitudinal observational study was conducted.
- Retrospective review of electronic medical records and study protocols from January 2011 to December 2021.
- Data from three major liver transplantation centers in southern Brazil were analyzed.
Main Results:
- Out of 1,362 LTs, 37 were for PSC.
- One-year and five-year patient survival rates were 83.8% and 80.6%, respectively.
- One-year and five-year graft survival rates were 83.8% and 74.8%, respectively. PSC recurrence was noted in 8.1% of cases.
Conclusions:
- LT in PSC patients demonstrated favorable patient and graft survival outcomes.
- The study confirms LT as an effective treatment for PSC.
- Common factors associated with LT mortality were observed in the PSC cohort.
