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Human Parechovirus Central Nervous System Infection in a Young Infant Cohort
Aspasia Katragkou1,2, Avni Sheth3, Christina Gagliardo1,2
1From the Infectious Diseases Division, Department of Pediatrics, Atlantic Health System, Goryeb Children's Hospital, Morristown, New Jersey.
A 2022 surge of pediatric human parechovirus (HPeV) central nervous system infections in infants showed similar clinical features. This highlights the need for better treatment evaluation and standardized follow-up for long-term prognosis.
Area of Science:
- Pediatric infectious diseases
- Virology
- Neurology
Background:
- Human parechovirus (HPeV) infections can cause severe central nervous system (CNS) disease in infants.
- A notable increase in pediatric HPeV CNS infections occurred in 2022 at our institution.
Purpose of the Study:
- To describe the clinical features of HPeV CNS infections during a 2022 surge.
- To emphasize the need for improved treatment strategies and long-term outcome assessment for affected infants.
Main Methods:
- Retrospective case review of infants diagnosed with HPeV CNS infections.
- Clinical data analysis including symptoms, severity, and outcomes.
Main Results:
- The 2022 surge involved a significant increase in HPeV CNS infection cases.
- Clinical presentations remained consistent with previous years despite the surge.
- No new or unusual clinical manifestations were identified during the surge.
Conclusions:
- The clinical course of HPeV CNS infections in infants did not change during the 2022 surge.
- Further research into treatment efficacy and standardized follow-up protocols is crucial.
- Understanding long-term prognosis for infants with HPeV infection requires ongoing investigation.
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