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Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
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An increase in a long noncoding RNA ANRIL in peripheral plasma is an indicator of stable angina

Yunjuan Jiao1, Fanming Meng2, Gaoen Ma3

  • 1Department of Histology and Embryology, School of Basic Medical Sciences, Central South University, China; Department of Pathology, School of Basic Medical Sciences, Xinxiang Medical University, China.

Clinics (Sao Paulo, Brazil)
|October 18, 2023
PubMed

Insights

Antisense Noncoding RNA gene in the INK4 Locus (ANRIL) is a better diagnostic indicator for stable angina than cardiac troponin I. Higher ANRIL levels in stable angina patients suggest its potential as a biomarker for coronary heart disease.

Area of Science:

  • Cardiovascular Medicine
  • Molecular Biology
  • Genetics

Background:

  • Stable angina is a manifestation of Coronary Heart Disease (CHD), potentially leading to severe complications.
  • The gene ANRIL (Antisense Noncoding RNA gene in the INK4 Locus) is linked to various disorders, including CHD.
  • Expression levels of ANRIL in stable angina versus myocardial infarction patients remain unclear.

Purpose of the Study:

  • To investigate and compare the diagnostic utility of ANRIL in stable angina and myocardial infarction.
  • To determine if ANRIL expression levels differ between patients with stable angina and myocardial infarction.

Main Methods:

  • Peripheral blood samples were collected from 59 stable angina patients, 62 myocardial infarction patients, and 48 healthy controls.
  • Real-time PCR was used to analyze ANRIL expression and cardiac troponin I levels.
  • ANRIL and cardiac troponin I were assessed before primary percutaneous coronary intervention.

Main Results:

  • ANRIL demonstrated superior diagnostic capability compared to cardiac troponin I in patients with stable angina.
  • ANRIL levels were significantly higher in patients diagnosed with stable angina than in those with myocardial infarction.

Conclusions:

  • ANRIL in peripheral plasma shows promise as a reliable biomarker for diagnosing stable angina.
  • Further research into ANRIL could enhance diagnostic strategies for coronary heart disease.
Abstract

Keywords:
ANRILAcute coronary syndromeCoronary heart diseaseMyocardial infarctionStable angina

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