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Published on: September 22, 2020
Primary antiphospholipid syndrome with and without limb ischemia: A retrospective observational study
Jozélio Freire de Carvalho1, Rodrigo A Brandão Neto2, Thelma Larocca Skare3
1Institute for Health Sciences from Federal University of Bahia, Salvador, Brazil.
Objective:
To compare clinical and laboratory data obtained from patients with primary Antiphospholipid Syndrome (PAPS) with and without limb ischemia (LI).
Methods:
A transverse study with 66 (83.3% female) PAPS patients was performed. All data were evaluated. Patients were subdivided into one of two groups: PAPS with LI and PAPS without LI and compared.
Results:
Sixty-six primary APS were selected. PAPS with LI group exhibited a longer disease duration (p = .012) and more arterial events (p = .002). A lower frequency of venous events was observed in PAPS with LI (p = .007), and deep venous thrombosis (p = .016). Furthermore, PAPS with LI patients had more deficiency of protein C of coagulation (p = .015) than the others.
Conclusion:
PAPS and LI have a distinct clinical and laboratory spectra from those without LI and it is characterized by an increased frequency of protein C deficiency, and a lower frequency of venous events, deep venous thrombosis and IgM anticardiolipin.
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