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Impact of Postoperative COVID-19 Infection Status on Outcomes in Elective Primary Total Joint Arthroplasty
Alyssa N Wenzel1, Majd Marrache1, Jessica Schmerler1
1Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Insights
Postoperative COVID-19 infection significantly increases risks for patients undergoing total joint arthroplasty (TJA), leading to higher rates of mortality, complications, and readmissions. Understanding these risks is crucial for orthopedic surgeons and patient counseling.
Area of Science:
- Orthopedic Surgery
- Infectious Diseases
- Public Health
Background:
- Coronavirus disease 2019 (COVID-19) poses significant morbidity and mortality risks.
- The impact of postoperative COVID-19 infection on total joint arthroplasty (TJA) outcomes remains unclear.
Purpose of the Study:
- To evaluate the 30-day outcomes for patients who contract COVID-19 after undergoing TJA.
- To compare outcomes between COVID-19-positive and COVID-19-negative patients following TJA.
Main Methods:
- Utilized the National Surgical Quality Improvement Program database for 2,340 TJA patients in 2021.
- Implemented propensity score matching to compare outcomes for postoperative COVID-19-positive and negative patients undergoing total hip arthroplasty (THA) and total knee arthroplasty (TKA).
Main Results:
- Postoperative COVID-19-positive THA patients showed increased risks of pneumonia, sepsis, readmission, and longer hospital stays.
- Postoperative COVID-19-positive TKA patients faced higher risks of 30-day mortality, infections, pulmonary embolism, myocardial infarction, reoperation, and extended hospital stays.
Conclusions:
- Patients contracting COVID-19 within 30 days after TJA experience elevated risks of mortality, medical complications, readmissions, reoperations, and non-home discharges.
- Orthopedic surgeons must counsel patients on these adverse outcomes and implement risk mitigation strategies, especially for high-risk populations.
Background:
Although Coronavirus disease 2019 (COVID-19) infection causes major morbidity and mortality, it is unclear what the impact of postoperative COVID-19 infection is on 30-day outcomes after total joint arthroplasty (TJA).
Methods:
There were 2,340 patients who underwent TJA in 2021, identified using the National Surgical Quality Improvement Program database, with 925 total hip arthroplasty (THA) patients (39.5%) and 1,415 total knee arthroplasty (TKA) patients (60.5%), overall. Propensity score matching was implemented using patient demographics and preoperative medical conditions to compare outcomes for postoperative COVID-19-positive and COVID-19-negative patients who underwent TKA or THA.
Results:
Postoperative COVID-19-positive THA patients were found to have a significantly increased risk of pneumonia (odds ratio [OR] 42.57), sepsis (OR 12.77), readmission (OR 12.06), non-home discharge (OR 3.78), and longer length of stay (hazard ratio 1.62). Postoperative COVID-19-positive TKA patients had an increased risk of 30-day mortality (OR 14.17), superficial infection (OR 3.17), pneumonia (OR 34.68), unplanned intubation (OR 18.31), ventilator use for more than 48 hours (OR 18.31), pulmonary embolism (OR 11.98), urinary tract infection (OR 5.16), myocardial infarction (OR 16.02), deep vein thrombosis (OR 4.69), non-home discharge (OR 1.79), reoperation (OR 3.17), readmission (OR 9.61), and longer length of stay (hazard ratio 1.49).
Conclusions:
Patients who contracted COVID-19 within 30 days after TJA were at increased risk of mortalities, medical complications, readmissions, reoperations, and non-home discharges. It is important for orthopedic surgeons to understand these adverse outcomes to better counsel patients and mitigate these risks, particularly in higher risk populations.
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