Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

23
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
23
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

17
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
17
Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

1.2K
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
1.2K
Cardiovascular Drugs: Classification based on Therapeutic Indications01:18

Cardiovascular Drugs: Classification based on Therapeutic Indications

2.9K
Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...
2.9K
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

14
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
14
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

1.3K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Demographic and geographic hotspots of Alzheimer's disease and pneumonia-related mortality among older adults in the United States: a retrospective analysis.

European journal of medical research·2026
Same author

Esophageal stenting and endoscopic vacuum therapy for esophageal defects: a systematic review and meta-analysis of observational studies.

Annals of medicine and surgery (2012)·2025
Same author

Cardiac myosin inhibitors - a cutting-edge solution for the management of hypertrophic cardiomyopathy: a narrative review.

Annals of medicine and surgery (2012)·2025
Same author

Efficacy and safety of repeat endoscopic submucosal dissection for recurrent, synchronous, and metachronous esophageal squamous cell carcinoma: a systematic review and meta-analysis.

Gastrointestinal endoscopy·2025
Same author

Tirofiban Combination Therapy for Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.

Brain and behavior·2025
Same author

Bridging surgical oncology and personalized medicine: the role of artificial intelligence and machine learning in thoracic surgery.

Annals of medicine and surgery (2012)·2025
Same journal

Implantable cardioverter-defibrillator in cardiac sarcoidosis: A propensity-score matched analysis.

Current problems in cardiology·2026
Same journal

Arterial Stiffness in Heart Failure with Preserved Ejection Fraction: is this a new Predisposing Factor?

Current problems in cardiology·2026
Same journal

The future of cardiovascular training: Bridging global disparities and building a hybrid model for equity in care.

Current problems in cardiology·2026
Same journal

Disparities in healthcare access and treatment outcomes for patients with chronic limb-threatening ischemia.

Current problems in cardiology·2026
Same journal

Diagnostic and prognostic value of coronary computed tomography angiography and high-risk plaque assessment in acute coronary syndrome.

Current problems in cardiology·2026
Same journal

Prognostic value of albuminuria in heart failure with preserved ejection fraction: A systematic review.

Current problems in cardiology·2026
See all related articles

Related Experiment Video

Updated: Jul 13, 2025

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
07:51

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis

Published on: September 26, 2018

7.6K

Rethinking HDL-C: An In-Depth Narrative Review of Its Role in Cardiovascular Health.

Prinka Perswani1, Syed Muhammad Ismail2, Hassan Mumtaz3

  • 1University of California, Riverside.

Current Problems in Cardiology
|October 18, 2023
PubMed
Summary
This summary is machine-generated.

Higher High-Density Lipoprotein Cholesterol (HDL-C) isn't always better for heart health. Genetic factors and extremely high HDL-C levels may unexpectedly increase cardiovascular disease (CVD) risk.

Keywords:
Cardiovascular outcomesCardiovascular risksHDL-CPublic Health

More Related Videos

Evaluation of Hydration Status by Bioelectrical Impedance Vector Analysis in Patients with Ischemic Heart Disease Undergoing Exercise Stress Test
10:21

Evaluation of Hydration Status by Bioelectrical Impedance Vector Analysis in Patients with Ischemic Heart Disease Undergoing Exercise Stress Test

Published on: September 22, 2023

659
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.3K

Related Experiment Videos

Last Updated: Jul 13, 2025

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
07:51

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis

Published on: September 26, 2018

7.6K
Evaluation of Hydration Status by Bioelectrical Impedance Vector Analysis in Patients with Ischemic Heart Disease Undergoing Exercise Stress Test
10:21

Evaluation of Hydration Status by Bioelectrical Impedance Vector Analysis in Patients with Ischemic Heart Disease Undergoing Exercise Stress Test

Published on: September 22, 2023

659
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.3K

Area of Science:

  • Cardiovascular Science
  • Lipid Metabolism
  • Genetics

Background:

  • High-Density Lipoprotein Cholesterol (HDL-C) is a key biomarker for cardiovascular disease (CVD) risk.
  • Traditionally, higher HDL-C levels were considered protective against CVD.
  • Recent findings suggest a more complex, non-linear relationship between HDL-C and cardiovascular outcomes.

Purpose of the Study:

  • To explore the complex relationship between HDL-C levels and cardiovascular outcomes.
  • To investigate the impact of genetic factors on HDL-C levels and associated CVD risk.
  • To challenge the conventional view that elevated HDL-C is universally beneficial.

Main Methods:

  • Review of current research on HDL-C, cardiovascular disease, and genetics.
  • Analysis of studies investigating associations between genetic determinants of HDL-C and CVD susceptibility.
  • Examination of emerging evidence on risks linked to ultra-high HDL-C levels.

Main Results:

  • Extremely high HDL-C levels, particularly those linked to genetic factors, may be associated with increased CVD risk.
  • The protective effect of HDL-C is not absolute and can be influenced by particle functionality and composition.
  • Low HDL-C remains a significant risk factor, but the role of very high HDL-C is nuanced.

Conclusions:

  • The association between HDL-C and cardiovascular outcomes is multifactorial and influenced by genetics.
  • Elevated HDL-C does not always confer protection and may, in some cases, increase CVD risk.
  • Further research is crucial to understand the intricate mechanisms and implications for CVD risk assessment and treatment.