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Related Concept Videos

Pharmacovigilance01:19

Pharmacovigilance

860
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
860
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

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5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
217
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

459
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
459
Glaucoma: Overview01:25

Glaucoma: Overview

599
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
599
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

536
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
536
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

305
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
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Updated: Jul 13, 2025

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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Ondansetron induced blindness: a pharmacovigilance database study.

R Barus1, C Potey2, S Gautier2

  • 1Department of Medical and Clinical Pharmacology, Centre of PharmacoVigilance and Pharmacoepidemiology, Toulouse University Hospital, Toulouse, France.

Expert Opinion on Drug Safety
|October 18, 2023
PubMed
Summary
This summary is machine-generated.

Ondansetron, an antiemetic drug, is rarely associated with blindness. This study found ondansetron increased the risk of blindness-related adverse drug reactions compared to other antiemetic drugs.

Keywords:
Adverse drug reactionVigiBaseblindnessdrug safetyondansetronpharmacovigilance

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Area of Science:

  • Pharmacovigilance
  • Clinical Pharmacology
  • Ophthalmology

Background:

  • Ondansetron is an antiemetic drug (AED) used to manage nausea and vomiting.
  • A rare risk of transient blindness, particularly with IV administration and chemotherapy, is noted in product information.
  • The study aimed to better characterize blindness associated with ondansetron use.

Purpose of the Study:

  • To analyze the incidence and characteristics of blindness-related adverse drug reactions (ADRs) linked to ondansetron.
  • To compare the reporting risk of blindness-related ADRs for ondansetron versus other AEDs.

Main Methods:

  • A descriptive and case/non-case analysis was conducted using VigiBase® data.
  • Blindness-related ADRs (amaurosis, amaurosis fugax, blindness) were identified as cases.
  • Disproportionality analysis, using Reporting Odds Ratios (ROR), assessed the reporting risk.

Main Results:

  • Out of 136,315 reported ADRs with AEDs, 136 were blindness-related, with 44 (32.4%) involving ondansetron.
  • Most ondansetron-related blindness ADRs occurred on the first day of use; 72% of patients recovered.
  • Ondansetron showed a significantly increased reporting risk for blindness-related ADRs (ROR = 4.00, p < 0.001) compared to other AEDs.

Conclusions:

  • Blindness is a rare adverse drug reaction associated with both intravenous and oral ondansetron.
  • Ondansetron use is linked to a higher reporting risk of blindness compared to other antiemetic drugs.